Lotiglipron
Based on 1 Customer Validation
Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. Lotiglipron reduces glucose and body weight, and can be used for research of Type 2 diabetes mellitus (T2DM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.96%
- CAS 番号: 2401892-75-7
- 分子式: C31H31ClN4O5
- 分子量:575.05
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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GPCR/G Protein Compound Library
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Clinical Compound Library
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Drug Repurposing Compound Library
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Anti-diabetic Compound Library
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Orally Active Compound Library
HY-L061
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Anti-Obesity Compound Library
HY-L087
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
生物活性
Lotiglipron exhibits moderate affinity to GLP-1R, Ki for mutated rat GLP-1R S33W is 2770 nM. Lotiglipron promotes the cAMP accumulation (EC50 on the high-density expressed mutant rat GLP-1R S33W is 26.9 nM), stimulates β-arrestin 1/2 recruitment (EC50 on the mutant rat GLP-1R S33W is 198 nM and 274 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2401892-75-7
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性状 Solid
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分子量 575.05
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分子式 C31H31ClN4O5
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Color White to off-white
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SMILES
C[C@@]1(C2=CC=C(C=N2)Cl)OC3=C(C4CCN(CC4)CC(N(C5=C6)C[C@@H]7CCO7)=NC5=CC=C6C(O)=O)C=CC=C3O1
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別名
PF-07081532
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (217.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7390 mL | 8.6949 mL | 17.3898 mL | 43.4745 mL |
| 5 mM | 0.3478 mL | 1.7390 mL | 3.4780 mL | 8.6949 mL | |
| 10 mM | 0.1739 mL | 0.8695 mL | 1.7390 mL | 4.3474 mL | |
| 15 mM | 0.1159 mL | 0.5797 mL | 1.1593 mL | 2.8983 mL | |
| 20 mM | 0.0869 mL | 0.4347 mL | 0.8695 mL | 2.1737 mL | |
| 25 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7390 mL | |
| 30 mM | 0.0580 mL | 0.2898 mL | 0.5797 mL | 1.4491 mL | |
| 40 mM | 0.0435 mL | 0.2174 mL | 0.4347 mL | 1.0869 mL | |
| 50 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8695 mL | |
| 60 mM | 0.0290 mL | 0.1449 mL | 0.2898 mL | 0.7246 mL | |
| 80 mM | 0.0217 mL | 0.1087 mL | 0.2174 mL | 0.5434 mL | |
| 100 mM | 0.0174 mL | 0.0869 mL | 0.1739 mL | 0.4347 mL |
Lotiglipron 関連分類
HY-153865 関連分類
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