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製品番号: HY-184384

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MetAP-2 modulator-1

MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₀H₁₅FN₄O₂S
分子量:394.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

MetAP-2 modulator-1 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

MetAP-2 modulator-1 (Compound 4e) (2.5 μg/mL; 24 h) significantly reduces MetAP-2 enzyme levels in human neuroblastoma SH-SY5Y cells, resulting in a measured level of 8.8 ng/μg protein after 24 h exposure at 2.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

2.5 μg/mL
Incubation Time:

24 h
Result:

Reduced MetAP-2 level to 8.8 ng/μg protein, which was a significant decrease compared to unexposed control cells (56.4 ng/μg protein) and positive control fumagillin (85.9 ng/μg protein).

化学情報

分子量 394.42
分子式 C₂₀H₁₅FN₄O₂S
SMILES

OC1=CC=C(C=C1)/C=N/NC(CC2=CSC3=NC(C4=CC=C(C=C4)F)=CN23)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Camci Eren M, et al. Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation. Bioorg Chem. 2026 Jun 1;180:110066. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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