MMP-9-IN-5
MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2581824-80-6
- 分子式: C27H20IN3O4
- 分子量:577.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MMP-9 4.49 nM (IC50) |
MMP-1 104 nM (IC50) |
MMP-2 266 nM (IC50) |
MMP-13 280 nM (IC50) |
AKT 1.34 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
3.1 nM
Compound: 8
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Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
| MCF7 | IC50 |
6.9 nM
Compound: 8
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Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
| NFS-60 | IC50 |
5.5 nM
Compound: 8
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Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
| WI-38 | IC50 |
35.1 nM
Compound: 8
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively[1].
MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively [1].
MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wi-38, MCF-7, NFS-60, HepG-2 cells
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Concentration:0-1 μM approximately
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Incubation Time:72 h
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Result:Showed cytotoxicity with IC50s: 35.1 nM (Wi-38), 6.9 nM (MCF-7), 5.5 nM (NFS-60), 3.1 nM (HepG-2).
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Cell Line:HepG-2
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Concentration:3.1 nM
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Incubation Time:24 h
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Result:Inhibited cell migration by 59.35%.
化学情報
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CAS 番号 2581824-80-6
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分子量 577.37
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分子式 C27H20IN3O4
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SMILES
O=C(C(N(C1=CC=CC=C1)C(C2=C(I)C=CC=C2)=O)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MMP-9-IN-5 関連分類
HY-146218 関連分類
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