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製品番号: HY-148022

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NSC 330770

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC₅₀ of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers.

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CAS 番号: 82585-91-9
分子式: C₁₆H₁₇N₅O₂
分子量:311.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC 330770 構造式

CAS 番号: 82585-91-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC₅₀ of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.0047 μM Compound: 1	The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line. The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line.	[PMID: 2299631]
L1210	IC₅₀	0.0047 μM Compound: 29	Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured	[PMID: 2231603]
L1210	IC₅₀	4.7 nM Compound: 1d	Inhibitory activity against lymphoid leukemia L1210 cells Inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2769680]
L1210	IC₅₀	4.7 nM Compound: 6	The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2795608]
L1210	IC₅₀	4.7 nM Compound: 6q	Cytotoxicity against lymphoid leukemia L1210 cells Cytotoxicity against lymphoid leukemia L1210 cells	[PMID: 1956035]

化学情報

CAS 番号 82585-91-9
分子量 311.34
分子式 C₁₆H₁₇N₅O₂
SMILES

O=C(NC1=NC(N)=C2N=C(CNC2=C1)C3=CC=CC=C3)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Barbier P, et al. Differential effects of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs modified at position C2 on tubulin polymerization, binding, and conformational changes. Biochemistry. 1995 Dec 26;34(51):16821-9. [Content Brief]

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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