OPC-163493
Based on 1 Customer Validation
OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.34%
- CAS 番号: 1644467-84-4
- 分子式: C14H8F3N5S
- 分子量:335.31
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
OPC-163493 (0.5-10 μM; 15 min) inhibits the production of Δψ and ROS in isolated rat liver mitochondria[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
OPC-163493 (1-10 mg/kg; Oral administration; 6 weeks) has an improved effect in diabetic rat model[1].
OPC-163493 (2-4 mg/kg; Oral administration; 2 weeks) has a lipid-lowering effect in rat models with high fat diet[1].
OPC-163493 (0.06% mixed chow; 51 days) has a protective effect in spontaneously hypertensive rat models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zucker diabetic fatty rats aged 11 weeks old[1]
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Dosage:1, 2, 4 and 10 mg/kg
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Administration:Oral administration (p.o.); 6 weeks
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Result:Suppressed HbA1c elevation in a dose-dependent manner.
Significantly lowered fasting blood glucose levels at doses of 4 and 10 mg/kg.
Had no significant effect on plasma insulin levels.
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Animal Model:HFD SD rats aged 12 weeks old[1]
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Dosage:2 and 4 mg/kg
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Administration:Oral administration (p.o.); 2 weeks
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Result:Did not affect body weight and food intake during the treatment period.
Slightly but significantly reduced fasting blood glucose after 2-week treatment.
Significantly reduced hepatic total TG, total diacylglycerol (DAG), and total cholesterol ester (CE) by 57%, 25%, and 26%, respectively even in the low-dose group.
Significantly reduced long-chain acylcarnitines (AC, C16 and C18).
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Animal Model:Salt-loaded stroke-prone spontaneously hypertensive rats (SHRSPs) aged 6 weeks old[1]
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Dosage:0.06% mixed chow
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Administration:Oral administration (p.o.); 51 days
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Result:Delayed stroke symptoms and death, lowered blood pressure.
Improved kidney function and urinary albumin-to-creatinine ratio, lowered uinary albumin excretion by 68%.
化学情報
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CAS 番号 1644467-84-4
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性状 Solid
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分子量 335.31
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分子式 C14H8F3N5S
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Color White to off-white
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SMILES
N#CC1=C(C2=C(C)SC(C3=CC=C(C(F)(F)F)C=C3)=N2)N=NN1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (372.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kanemoto N, et al. Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler. Nat Commun. 2019 May 15;10(1):2172. [Content Brief]
[2]. Inoue Y, et al. Preclinical safety profile of a liver-localized mitochondrial uncoupler: OPC-163493. EXCLI J. 2022 Jan 11;21:213-235. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9823 mL | 14.9116 mL | 29.8231 mL | 74.5579 mL |
| 5 mM | 0.5965 mL | 2.9823 mL | 5.9646 mL | 14.9116 mL | |
| 10 mM | 0.2982 mL | 1.4912 mL | 2.9823 mL | 7.4558 mL | |
| 15 mM | 0.1988 mL | 0.9941 mL | 1.9882 mL | 4.9705 mL | |
| 20 mM | 0.1491 mL | 0.7456 mL | 1.4912 mL | 3.7279 mL | |
| 25 mM | 0.1193 mL | 0.5965 mL | 1.1929 mL | 2.9823 mL | |
| 30 mM | 0.0994 mL | 0.4971 mL | 0.9941 mL | 2.4853 mL | |
| 40 mM | 0.0746 mL | 0.3728 mL | 0.7456 mL | 1.8639 mL | |
| 50 mM | 0.0596 mL | 0.2982 mL | 0.5965 mL | 1.4912 mL | |
| 60 mM | 0.0497 mL | 0.2485 mL | 0.4971 mL | 1.2426 mL | |
| 80 mM | 0.0373 mL | 0.1864 mL | 0.3728 mL | 0.9320 mL | |
| 100 mM | 0.0298 mL | 0.1491 mL | 0.2982 mL | 0.7456 mL |
OPC-163493 関連分類
HY-134769 関連分類
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