1644467-84-4
1644467-84-4
Chemical Structure
OPC-163493
- CAS. Nr.: 1644467-84-4
- Formula:C14H8F3N5S
- Molecular Weight:335.31
IUPAC Name: 4-(5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)-1H-1,2,3-triazole-5-carbonitrile
InChIKey: HRPOFNGLAQYGDC-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=C(C)SC(C3=CC=C(C(F)(F)F)C=C3)=N2)N=NN1
Biological Activity: OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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OPC-163493 | 99.34% | OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease. | ||||||||||||||||||||
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References
- [1]. Kanemoto N, et al. Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler. Nat Commun. 2019 May 15;10(1):2172. [Content Brief]
- [2]. Inoue Y, et al. Preclinical safety profile of a liver-localized mitochondrial uncoupler: OPC-163493. EXCLI J. 2022 Jan 11;21:213-235. [Content Brief]
