PF-6870961
PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2857112-06-0
- 分子式: C29H32N6O2S
- 分子量:528.67
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Satiated and fasted rats model[1]
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Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
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Administration:Intraperitoneal injection
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Result:Significantly reduced food intake at 40 mg/kg.
化学情報
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CAS 番号 2857112-06-0
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分子量 528.67
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分子式 C29H32N6O2S
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SMILES
CC1=CN(C(S1)=N2)C=C2CC(N3CCC4(CC3)CN([C@H]5C6=CC=C(C7=NC(O)=NC(C)=C7)C=C6CC5)C4)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PF-6870961 関連分類
HY-153095 関連分類
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