Ruzasvir
Based on 1 Customer Validation
Ruzasvir (MK-8408) is an orally active inhibitor for genotypic HCV nonstructural protein 5A (NS5A), which inhibits the replication of NS5A mutants GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a and GT4a with EC90 ranging from 0.003 to 0.067 nM. Ruzasvir exhibits good pharmacokinetic characters in rhesus monkey model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.78%
- CAS 番号: 1613081-64-3
- 分子式: C49H55FN10O7S
- 分子量:947.09
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1613081-64-3
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性状 Solid
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分子量 947.09
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分子式 C49H55FN10O7S
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Color Light yellow to yellow
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SMILES
FC1=C2C3=CC4=CC(C5=CN=C([C@H](CCC6)N6C([C@H](C(C)C)NC(OC)=O)=O)N5)=CC=C4N3[C@H](C7=CN=C(C8CC8)S7)OC2=CC(C9=CN=C([C@H](CCC%10)N%10C([C@H](C(C)C)NC(OC)=O)=O)N9)=C1
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別名
MK-8408
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (105.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0559 mL | 5.2793 mL | 10.5587 mL | 26.3966 mL |
| 5 mM | 0.2112 mL | 1.0559 mL | 2.1117 mL | 5.2793 mL | |
| 10 mM | 0.1056 mL | 0.5279 mL | 1.0559 mL | 2.6397 mL | |
| 15 mM | 0.0704 mL | 0.3520 mL | 0.7039 mL | 1.7598 mL | |
| 20 mM | 0.0528 mL | 0.2640 mL | 0.5279 mL | 1.3198 mL | |
| 25 mM | 0.0422 mL | 0.2112 mL | 0.4223 mL | 1.0559 mL | |
| 30 mM | 0.0352 mL | 0.1760 mL | 0.3520 mL | 0.8799 mL | |
| 40 mM | 0.0264 mL | 0.1320 mL | 0.2640 mL | 0.6599 mL | |
| 50 mM | 0.0211 mL | 0.1056 mL | 0.2112 mL | 0.5279 mL | |
| 60 mM | 0.0176 mL | 0.0880 mL | 0.1760 mL | 0.4399 mL | |
| 80 mM | 0.0132 mL | 0.0660 mL | 0.1320 mL | 0.3300 mL | |
| 100 mM | 0.0106 mL | 0.0528 mL | 0.1056 mL | 0.2640 mL |
Ruzasvir 関連分類
HY-101663 関連分類
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