SLU-11695
SLU-11695 is an orally active antiparasitic agent belonging to the pyrazolo[3,4-d]pyrimidine benzoxaborole class. SLU-11695 inhibits the asexual reproduction of Cryptosporidium parvum, eliminates parasite shedding, and prevents post-exposure recurrence. SLU-11695 can be used in the research of cryptosporidiosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3065121-95-8
- 分子式: C23H23BFN5O2
- 分子量:431.27
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | EC50 |
0.025 μM
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Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.
Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.
|
42593902 |
| HCT-8 | CC50 |
~77 μM
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Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.
Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.
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42593902 |
体外実験
SLU-11695 (0.025 μM; 48 h) potently inhibits Cryptosporidium parvum growth in HCT-8 cells with an EC50 of 0.025 μM and exhibits >3000-fold selectivity over host cell cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (male, 4-5 weeks old)[1]
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Dosage:50 mg/kg
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Administration:p.o.; twice daily; 4 days
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Result:Eliminated *C. parvum* fecal shedding with no evidence of relapse up to 8 days after dosing cessation.
Showed no apparent side effects in all tested mice.
化学情報
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CAS 番号 3065121-95-8
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分子量 431.27
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分子式 C23H23BFN5O2
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SMILES
CCC1=NN(C)C2=NC(C3=CC=C(B(O)OC4C)C4=C3)=NC(NCC5=CC=C(F)C=C5)=C21
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SLU-11695 関連分類
HY-189004 関連分類
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