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製品番号: HY-186144

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WMK-2

WMK-2 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer with broad-spectrum anticancer activity. WMK-2 generates hydroxyl radicals and lipid ROS to induce ferroptosis in cancer cells and cancer stem cells. WMK-2 can be used for the research of cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2814563-63-6
分子式: C₃₈H₄₉BrNO₆P
分子量:726.68

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

WMK-2 構造式

CAS 番号: 2814563-63-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

WMK-2 (37b) showed potent and broad-spectrum antiproliferative activity across numerous cancer cell lines. It potently inhibited MDA-MB-231, HCT116, T47D, HepG2, HeLa, HEK293, MCF7, PLC, U2OS, and Huh7 cells with IC₅₀ values of 0.38, 0.6, 0.62, 0.7, 1.6, 1.6, 2.4, 2.7, 3.4, and 3.8 μM, respectively. Meanwhile, WMK-2 displayed favorable selectivity toward normal cells, with IC₅₀ values of 4.6 μM (NIH3T3), 5.2 μM (bEnd.3), and 9.5 μM (MDCK), corresponding to a selectivity index greater than 7.6^[1].
WMK-2 (48 h) inhibits HeyA8 adherent ovarian cancer cell viability with an IC₅₀ of 1.4 μM and HeyA8 ovarian cancer stem cell spheroid viability with an IC₅₀ of 1.1 μM after 48 h of incubation, showing a selectivity index greater than 11 relative to non-cancerous NIH3T3 cells^[1].
WMK-2 induces ferroptosis in both HeyA8 ovarian cancer stem cells and MDA-MB-231 breast cancer cells^[1].
WMK-2 (1 μM; 6 h) induces significant lipid ROS generation in MDA-MB-231 breast cancer cells, confirming ferroptosis-associated lipid peroxidation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

WMK-2 (37b) (5-10 mg/kg; i.p.) effectively inhibited tumor growth in both MDA-MB-231 breast cancer and HEYA8 CSC ovarian cancer xenograft nude mice, with no observed histopathological abnormalities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice (female, HEYA8 CSC xenograft model)^[1]
Dosage:

5 mg/kg; 10 mg/kg
Administration:

i.p.
Result:

Effectively inhibited ovarian tumor growth compared with vehicle control.
Showed well-tolerated safety profile with no abnormal behavior or weight loss noted during treatment period.

化学情報

CAS 番号 2814563-63-6
分子量 726.68
分子式 C₃₈H₄₉BrNO₆P
SMILES

CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)=O)CC3)OO2)CC1.[Br-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Dan Yang, et al. Targeted delivery of 1, 2, 4, 5-tetraoxane compounds and their uses, WO, WO2022161490A1, 2022-08-04.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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