κ-Carrageenase, Zobellia Galactanivorans
κ-Carrageenase from Zobellia galactanivorans (EC 3.2.1.83) is an enzyme systematically named κ-carrageenan 4-β-D-glycanohydrolase (configuration-retaining). κ-Carrageenase from Zobellia galactanivorans hydrolyzes κ-carrageenan in an endolytic manner, primarily producing κ-neocarratetraose (DP4) and κ-neocarrahexaose (DP6). κ-Carrageenase, Zobellia galactanivorans generates κ-carrageenan oligosaccharides (κ-COS) that exhibit antioxidant, immunomodulatory, antitumor, anticoagulant, and antiviral activities via Nrf2/NF-κB/AMPK and other pathways; the enzyme itself possesses only catalytic activity and no direct pharmacological effects.
For research use only. We do not sell to patients.
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
The catalytic domain of κ-carrageenase from Zobellia galactanivorans (ZgCgkA_GH16) has a kcat/Km value of 1.11 × 109 M-1s-1 for degrading soluble κ-carrageenan[1].
Compared with the standalone catalytic module, the full-length κ-carrageenase from Zobellia galactanivorans (0.2% (w/v), 3.5 nM enzyme, 14 nM enzyme; 15 min-1 week), designated ZgCgkA_GH16-CBM16-PorSS, preferentially releases DP4 oligosaccharides rather than DP6 oligosaccharides, with a DP4/DP6 ratio reaching 11.12 after 1 week of incubation[1].
The catalytic domain of κ-carrageenase from Zobellia galactanivorans (ZgCgkA_GH16) possesses a unique β-jelly roll fold architecture with a distinct finger-like region and enhanced flexibility of key channel segments, at a resolution of 1.66 Å[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
SMILES
[κ-Carrageenase, Zobellia Galactanivorans]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
κ-Carrageenase, Zobellia Galactanivorans Related Classifications
HY-E71350 Related Classifications
Powered by Bioz