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Cat. No.: HY-112481

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IKK2-IN-5

IKK2-IN-5 is a selective IKK-2 inhibitor with an IC₅₀ of 0.025 μM. IKK2-IN-5 inhibits the production of TNF-α in LPS (HY-D1056)-stimulated human peripheral blood mononuclear cells. IKK2-IN-5 exhibits extremely low cytotoxicity against human peripheral blood mononuclear cells.

For research use only. We do not sell to patients.

CAS No.: 354810-80-3
Formula: C₁₂H₁₁N₃O₂S
Molecular Weight:261.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IKK2-IN-5 Chemical Structure

CAS No.: 354810-80-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

IKK2-IN-5 (compound 4) (16.5 h) inhibits LPS (HY-D1056)-induced TNF-α production in human PBMCs with an IC₅₀ of 0.25 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 354810-80-3
Molecular Weight 261.30
Formula C₁₂H₁₁N₃O₂S
SMILES

O=C(N)NC=1C=C(SC1C(=O)N)C=2C=CC=CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Baxter A, et al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004;14(11):2817-2822. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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