Acrofolione A
Acrofolione A is an acetophenone dimer isolated from Acronychia pendunculata with anticancer effects. Acrofolione A induces G0/G1 phase cell cycle arrest and apoptosis in human NALM-6 pre-B cell leukaemia cells. Acrofolione A can be used for leukaemia research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 820975-61-9
- 화학식: C32H42O9
- 분자량:570.67
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Acrofolione A (48 h) suppresses the growth of NALM-6, K562 and HPB-ALL cells with IC50 values of 16.7, 17.9, and 10.1 μM, respectively[1].
Acrofolione A (10-20 μM, 6-48 h) induces G0/G1-phase cell cycle arrest and promotes apoptosis in NALM-6 cells, as demonstrated by decreased mitochondrial membrane potential, elevated caspase 3/7 activity, increased levels of cleaved PARP and cleaved caspase-3/7, and reduced expression of survivin protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 820975-61-9
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분자량 570.67
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화학식 C32H42O9
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SMILES
CC(C)CC(C1=C(C(C/C=C(C)\C)=C(C(C(C)=O)=C1O)OC)O)C2=C3C(CC(O3)C(C)(O)C)=C(C(C(C)=O)=C2O)O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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