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Cat. No.: HY-P12261

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AJICAP reagent 6b

AJICAP reagent 6b is an Fc-affinity peptide reagent that site-specifically modifies Lys288 of native antibodies via thiophenyl ester chemistry. AJICAP reagent 6b enables site-specific conjugation of native antibodies at Lys288 with high conversion yield and reduced aggregation. AJICAP reagent 6b can be used for the research of cancer.

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화학식: C₁₉₁H₂₉₀N₆₀O₅₉S₅
분자량:4531.04

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

AJICAP reagent 6b Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

AJICAP reagent 6b (6 equivalents; 1 h) enables efficient site-specific Lys288 conjugation of various native antibodies, producing homogeneous conjugates with a PAR of 2.0 and minimal aggregation^[1].
AJICAP reagent 6b-derived antibody-thiols can be applied to produce antibody-oligonucleotide conjugates^[1].
AJICAP reagent 6b-derived antibody-thiols can be applied to produce antibody-protein conjugates^[1].
AJICAP reagent 6b-derived antibody-thiols (2.7 equivalents; 1 h) are compatible with various payload linkers, producing Lys288-conjugated ADCs with DAR values near 2 and low aggregation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 4531.04
화학식 C₁₉₁H₂₉₀N₆₀O₅₉S₅
Sequence

Ac-Phe-Asn-Met-Gln-Cys-Gln-Arg-Arg-Phe-Tyr-Glu-Ala-Leu-His-Asp-Pro-Asn-Leu-Asn-Glu-Glu-Gln-Arg-Asn-Ala-Arg-Ile-Arg-Ser-Ile-Lys(4-oxo-4-((3-oxo-3-(phenylthio)propyl)thio)butanoic acid)-Asp-Asp-Cys-NH2 (disulfide bridge:Cys5-Cys34)
Sequence Shortening

Ac-FNMQCQRRFYEALHDPNLNEEQRNARIRSI-Lys(4-oxo-4-((3-oxo-3-(phenylthio)propyl)thio)butanoic acid)-DDC-NH2 (disulfide bridge:Cys5-Cys34)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Fujii T, et al. AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production. Bioconjugate chemistry. 2023 Mar 09;34(4):728-38. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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