Antibacterial agent 166
Antibacterial agent 166 (Compound 19q), a derivative of Nitisinone (HY-B0607), is a selective and orally active Fusobacterium nucleatum inhibitor with a MIC50 of 1 μg/mL. Antibacterial agent 166 effectively attenuates the migratory ability of MC-38 cells induced by Fusobacterium nucleatum. Antibacterial agent 166 is a promising anti-F. nucleatum lead compound and can be used for colorectal cancer (CRC) research.
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- 화학식: C11H8ClN3O4
- 분자량:281.65
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Antibacterial agent 166 (Compound 19q) (1-4 μg/mL, 0-72 h) inhibits the growth and biofilm formation of Fusobacterium nucleatum in a dose dependent manner[1].
Antibacterial agent 166 (1-4 μg/mL, 4-48 h) inhibits the growth of Fusobacterium nucleatum by downregulating the expression of NTR[1].
Antibacterial agent 166 (1-4 μg/mL, 48 h) downregulates the expression of the tnaA gene in the late-log-phase in a dose-dependent manner[1].
Antibacterial agent 166 (2-4 μg/mL, 48 h) possesses stronger migratory inhibition potency against MC-38 under the stimulation of Fusobacterium nucleatum[1].
Antibacterial agent 166 exhibits the most potent inhibitory activity against MC-38 cells, with an IC50 of 11 μM[1].
Antibacterial agent 166, exhibits moderate to weak antiproliferative activity two human normal cell lines with an IC50 of 16 μM, possess low cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Antibacterial agent 166 (20 mg/kg, p.o, single dose) can inhibit Fusobacterium nucleatum locally in the intestinal tract and has lower systemic toxicity[1].
Antibacterial agent 166 (1 mg/kg, Intravenous injection) half-life is approximately 0.068 h, the peak concentration Cmax and plasma clearance (CL) were 85 ng/mL and 36054 mL/h/mg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 281.65
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화학식 C11H8ClN3O4
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SMILES
ClC1=CN=C(CNC(C2=CC=C([N+]([O-])=O)O2)=O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 166 Related Classifications
HY-155491 Related Classifications
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