country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187734

Copy Link Print Information

AY 17605

AY 17605 is a nucleoside-3':5'-monophosphate phosphodiesterase (Phosphodiesterase) inhibitor that blocks cAMP hydrolysis through non-competitive inhibition, thereby elevating intracellular cAMP levels. AY 17605 can be used in studies related to cardiotonic activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 7755-28-4
화학식: C₂₅H₃₆O₅
분자량:416.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY 17605 Chemical Structure

CAS No.: 7755-28-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Phosphodiesterase (PDE) Isoforms :

In Vitro

AY 17605 (preincubation 5 min; PDE reaction 1 min) is a potent non-competitive inhibitor of purified bovine heart nucleoside-3':5'-monophosphate phosphodiesterase, with an IC₅₀ of 44 μM^[1].
AY 17605 (0.1 μM; 5 min preincubation, 1.5 min PDE reaction) exhibits only weak inhibitory activity against purified rat brain nucleoside-3':5'-monophosphate phosphodiesterase^[1].
AY 17605 is a non-competitive inhibitor of bovine heart nucleoside-3':5'-monophosphate phosphodiesterase, with an IC₅₀ of 44 μM and a K_i of 0.064 μM^[2].
AY 17605 (0.1 μM) exhibits only moderate inhibitory activity against rat brain nucleoside-3':5'-monophosphate phosphodiesterase, producing 24% inhibition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7755-28-4
분자량 416.56
화학식 C₂₅H₃₆O₅
SMILES

O[C@@]12[C@@](C)([C@H](CC1)C=3C(=O)OCC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](OC(C)=O)C5)[H])[H])[H]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lippmann W. Inhibition of beef heart and rat brain nucleoside-3':5'-monophosphate phosphodiesterase by 3beta-14-dihydroxy-21-oxo-23-desoxo-5-beta-card-20(22)-enolide 3-acetate (AY-17,605) and structurally related compounds. Experientia. 1974 Mar 15;30(3):237-9.

[2]. Balogun RA. Amino acids in the excreta of the tsetse fly, Glossina palpalis. Experientia. 1974 Mar 15;30(3):239-40.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기