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Cat. No.: HY-187400A

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DOPE-PEG2000-YIGSR

(Synonyms: DOPE-PEG2000-Mal-Cys-YIGSR)

DOPE-PEG2000-YIGSR (DOPE-PEG2000-Mal-Cys-YIGSR) is an amphiphilic lipid-PEG-peptide conjugate consisting of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the YIGSR peptide (Tyr-Ile-Gly-Ser-Arg), a sequence derived from the beta-1 chain of laminin. YIGSR peptide binds to the 67 kDa laminin receptor that is overexpressed on various tumor cells. DOPE-PEG2000-YIGSR is used for tumor-targeted drug delivery and anti-metastatic research.

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보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-YIGSR Chemical Structure

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Biological Activity

제품 설명

In Vitro

DOPE-PEG2000-YIGSR: surface modification of liposomes and nanoparticles for laminin receptor-targeted drug delivery to tumor cells, and for anti-metastatic therapy by blocking tumor cell adhesion and invasion.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two unsaturated oleoyl chains that anchors into lipid membranes and promotes pH-responsive membrane fusion for endosomal escape;
(2) PEG2000; a hydrophilic polymer that creates a stealth layer reducing immune clearance and prolonging circulation half-life;
(3) YIGSR peptide; a pentapeptide derived from laminin beta-1 chain that specifically binds to the 67 kDa laminin receptor overexpressed on tumor cells, enabling active targeting while also competitively inhibiting tumor cell adhesion to basement membranes, thereby suppressing metastasis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-YIGSR]
Synonyms

DOPE-PEG2000-Mal-Cys-YIGSR
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.