Prkcg - protein kinase C, gamma Gene

Also Known as PKC; PKCI; Prkc; Prkcc; RATPKCI

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24681

About Prkcg

Primary_assembly 1: 65,832,855-65,859,384 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 201 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 143.9), Spleen (RPKM 12.) and 2 other tissues.

Summary

Enables calcium-dependent protein kinase C activity. Involved in several processes, including long-term synaptic potentiation; protein autophosphorylation; and response to psychosocial stress. Located in several cellular components, including dendrite; perinuclear region of cytoplasm; and synaptic membrane. Is active in postsynaptic cytosol. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Apr 2022]

Prkcg Products (2)

mRNA	Protein	Name
NM_012628.2	NP_036760.1	protein kinase C gamma type
NM_012628.2	NP_036760.1	protein kinase C gamma type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18972403	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8940095	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in learning or memory	IEP IEP: Inferred from expression pattern	12000125	RGD
involved in long-term synaptic potentiation	IDA IDA: Inferred from direct assay	10501452	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15705736	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18972403	RGD
involved in response to angiotensin	IDA IDA: Inferred from direct assay	11507002	RGD
involved in response to psychosocial stress	IDA IDA: Inferred from direct assay	9287082	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	12560106	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11507002	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12471040	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12471040	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12471040	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	2202488	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	12560106	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcg Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt2

C2_PKC_alpha_gamma

STKc_cPKC

0
200
400
600
697 a.a.

Protein Preferred Names	Protein Names
protein kinase C gamma type	PKC-gamma protein kinase C type I (gamma type)

Prkcg Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Prkcg	P63319	LIMK1	Homo sapiens	P53667	Anti Tag CoIP	8940095

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	Purity	Rare Diseases
HY-RS11128	PRKCG Human Pre-designed siRNA Set A	/	Unkown
HY-RS11129	Prkcg Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11130	Prkcg Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcg	NCBI	NCBI:5582