L-Ala-BPA
Based on 1 Customer Validation
L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.0%
- CAS No.: 2941355-27-5
- 화학식: C12H17BN2O5
- 분자량:280.08
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in AsPC-1 cells via the PEPT1/2 transport pathway[1].
L-Ala-BPA (2 h) mediates dose-dependent boron uptake in FaDu cells via the LAT-1 transport pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colon carcinoma BALB/c mice[1]
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Dosage:200 mg/kg
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Administration:i.v.; single bolus dose; 90 minutes prior to neutron irradiation
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Result:Induced complete and durable tumor control through the study endpoint.
Produced a 34% growth delay in non-irradiated abscopal tumors.
Chemical Information
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CAS No. 2941355-27-5
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Appearance Solid
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분자량 280.08
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화학식 C12H17BN2O5
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Color White to off-white
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SMILES
OB(O)C1=CC=C(C[C@H](NC([C@H](C)N)=O)C(O)=O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Ala-BPA Related Classifications
HY-183513 Related Classifications
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