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Cat. No.: HY-184384

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MetAP-2 modulator-1

MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₀H₁₅FN₄O₂S
분자량:394.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

MetAP-2 modulator-1 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

MetAP-2 modulator-1 (Compound 4e) (2.5 μg/mL; 24 h) significantly reduces MetAP-2 enzyme levels in human neuroblastoma SH-SY5Y cells, resulting in a measured level of 8.8 ng/μg protein after 24 h exposure at 2.5 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

2.5 μg/mL
Incubation Time:

24 h
Result:

Reduced MetAP-2 level to 8.8 ng/μg protein, which was a significant decrease compared to unexposed control cells (56.4 ng/μg protein) and positive control fumagillin (85.9 ng/μg protein).

Chemical Information

분자량 394.42
화학식 C₂₀H₁₅FN₄O₂S
SMILES

OC1=CC=C(C=C1)/C=N/NC(CC2=CSC3=NC(C4=CC=C(C=C4)F)=CN23)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Camci Eren M, et al. Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation. Bioorg Chem. 2026 Jun 1;180:110066. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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