Neoliquiritin
Based on 1 publication(s) in Google Scholar
Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions.
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- Purity: 99.85%
- CAS No.: 5088-75-5
- 화학식: C21H22O9
- 분자량:418.39
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
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Publications Citing Use of MedChemExpress (MCE) Neoliquiritin
MoreAll Caspase Isoforms
More
Biological Activity
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Caspase 3 |
Caspase-7 |
Neoliquiritin (48 h after 48 h initial cell seeding) shows moderate, cell-dependent cytotoxicity against HSC-2, HSC-3, HSC-4, HL-60 tumor cells and HGF, HPC, HPLF normal cells, with a tumor-specificity index of 0.264[2].
Neoliquiritin (2.5-10 µg/mL; 24 h) significantly increases the viability of SH-SY5Y cells[3].
Neoliquiritin (2.5-10 µg/mL; 2 h pre-treatment, followed by 24 h incubation with MPP+) significantly protects SH-SY5Y cells from MPP+-induced neurotoxicity, restoring cell viability to ~80% of control[3].
Neoliquiritin (2.5 µg/mL; 2 h pre-treatment, followed by 24 h incubation with MPP+) significantly attenuates MPP+-induced elevation of caspase 3/7 activity in SH-SY5Y cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human neuroblastoma SH-SY5Y cells
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Concentration:2.5 µg/mL; 5 µg/mL; 10 µg/mL
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Incubation Time:24 h
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Result:Increased cell viability significantly relative to control at 2.5 µg/mL.
Increased cell viability significantly relative to control at 5 µg/mL.
Increased cell viability significantly relative to control at 10 µg/mL.
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Cell Line:human neuroblastoma SH-SY5Y cells exposed to MPP+
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Concentration:2.5 µg/mL; 5 µg/mL; 10 µg/mL
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Incubation Time:2 h pre-treatment, followed by 24 h incubation with MPP+
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Result:Restored cell viability to ~80% of control relative to MPP+-treated cells at 2.5 µg/mL.
Restored cell viability to ~80% of control relative to MPP+-treated cells at 5 µg/mL.
Restored cell viability to ~80% of control relative to MPP+-treated cells at 10 µg/mL.
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Cell Line:human neuroblastoma SH-SY5Y cells exposed to MPP+
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Concentration:2.5 µg/mL
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Incubation Time:2 h pre-treatment, followed by 24 h incubation with MPP+
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Result:Reduced caspase 3/7 activity to ~1.5-fold of control relative to MPP+-treated cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming mice with Non-alcoholic fatty liver disease (male, 8 weeks old, 20 g)[1]
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Dosage:87.5 mg/kg; 175 mg/kg; 350 mg/kg
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Administration:p.o.; daily; 4 weeks
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Result:Reduced hepatic TG to 166.22 μmol/g, and reduced relative area of hepatic fat vacuoles by 73.68% at 87.5 mg/kg.
Reduced hepatic MDA to 2.12 nmol/g, hepatic cholesterol to 0.100 mmol/g, hepatic TG to 147.33 μmol/g, and reduced relative area of hepatic fat vacuoles by 79.53% at 175 mg/kg.
Reduced hepatic MDA to 1.99 nmol/g, hepatic cholesterol to 0.096 mmol/g, hepatic TG to 128.45 μmol/g, and reduced relative area of hepatic fat vacuoles by 85.14% at 350 mg/kg.
Chemical Information
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CAS No. 5088-75-5
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Appearance Solid
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분자량 418.39
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화학식 C21H22O9
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Color White to yellow
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SMILES
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C13
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Med Chem
Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]2025 Sep 27:131:118423. PMID: 41033076
용액&용해도
DMSO : 250 mg/mL (597.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
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- Italian - IT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | 59.7529 mL |
| 5 mM | 0.4780 mL | 2.3901 mL | 4.7802 mL | 11.9506 mL | |
| 10 mM | 0.2390 mL | 1.1951 mL | 2.3901 mL | 5.9753 mL | |
| 15 mM | 0.1593 mL | 0.7967 mL | 1.5934 mL | 3.9835 mL | |
| 20 mM | 0.1195 mL | 0.5975 mL | 1.1951 mL | 2.9876 mL | |
| 25 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3901 mL | |
| 30 mM | 0.0797 mL | 0.3984 mL | 0.7967 mL | 1.9918 mL | |
| 40 mM | 0.0598 mL | 0.2988 mL | 0.5975 mL | 1.4938 mL | |
| 50 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1951 mL | |
| 60 mM | 0.0398 mL | 0.1992 mL | 0.3984 mL | 0.9959 mL | |
| 80 mM | 0.0299 mL | 0.1494 mL | 0.2988 mL | 0.7469 mL | |
| 100 mM | 0.0239 mL | 0.1195 mL | 0.2390 mL | 0.5975 mL |
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