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Cat. No.: HY-148022

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NSC 330770

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC₅₀ of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers.

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CAS No.: 82585-91-9
화학식: C₁₆H₁₇N₅O₂
분자량:311.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC 330770 Chemical Structure

CAS No.: 82585-91-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC₅₀ of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.0047 μM Compound: 1	The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line. The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line.	[PMID: 2299631]
L1210	IC₅₀	0.0047 μM Compound: 29	Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured	[PMID: 2231603]
L1210	IC₅₀	4.7 nM Compound: 1d	Inhibitory activity against lymphoid leukemia L1210 cells Inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2769680]
L1210	IC₅₀	4.7 nM Compound: 6	The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells	[PMID: 2795608]
L1210	IC₅₀	4.7 nM Compound: 6q	Cytotoxicity against lymphoid leukemia L1210 cells Cytotoxicity against lymphoid leukemia L1210 cells	[PMID: 1956035]

Chemical Information

CAS No. 82585-91-9
분자량 311.34
화학식 C₁₆H₁₇N₅O₂
SMILES

O=C(NC1=NC(N)=C2N=C(CNC2=C1)C3=CC=CC=C3)OCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Barbier P, et al. Differential effects of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs modified at position C2 on tubulin polymerization, binding, and conformational changes. Biochemistry. 1995 Dec 26;34(51):16821-9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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