PHGDH-IN-2
PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells.
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- 화학식: C22H20N4O3S
- 분자량:420.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
PHGDH[1]
In Vitro
PHGDH-IN-2 (compound C25) (10, 30 µM) inhibits the serine synthetic pathway in MDA-MB-468 cells[1].
PHGDH-IN-2 (72 h) inhibits the growth of PHGDH-dependent cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MDA-MB-468, NCI-H1975, HCC827, PC-9, ZR-75–1, MDA-MB-231 cells
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Concentration:
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Incubation Time:72 h
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Result:Inhibited the growth of PHGDH-dependent cancer cells.
Chemical Information
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분자량 420.48
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화학식 C22H20N4O3S
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SMILES
CN1C(C(NC2=CC=CC(NS(=O)(C3=CC=C(C=C3)N)=O)=C2)=O)=CC4=C1C=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PHGDH-IN-2 Related Classifications
HY-145860 Related Classifications
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