country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-174827

Copy Link Print Information

POLRMT-IN-2

POLRMT-IN-2 is a potent POLRMT inhibitor. POLRMT-IN-2 exhibits strong antiproliferative activity in MOLM-13 cells, with an IC₅₀ of 1.01 μM. POLRMT-IN-2 disrupts mitochondrial function and induces apoptosis in MOLM-13cells. POLRMT-IN-2 can be used for the study of acute myeloid leukemia(AML).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₄H₃₂N₄O₅
분자량:576.64

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

POLRMT-IN-2 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

POLRMT-IN-2 (Compound 10a) (0-100 μM, 48 h) inhibits POLRMT activity dose-dependently in MOLM-13 cells, with an EC₅₀ value of 2.208 μΜ for ND1 expression suppression^[1].

POLRMT-IN-2 (48 h) shows anti-proliferation activity in cells with IC₅₀s of 1.01 μΜ (MOLM-13 cells), 3.24 μΜ (MV4-11 cells) and 14.17 μΜ (HL-60 cells)^[1].

POLRMT-IN-2 (5 μM, 48 h) can inhibit the proliferation of MOLM-13 cells, as evidenced by the reduction in EdU-positive cells and decreased Ki67 expression^[1].

POLRMT-IN-2 (0-10 μM, 48 h) disrupts mitochondrial function in MOLM-13 cells, as demonstrated by dose-dependent increases in ROS levels, decreases in ATP content, and reduction of mitochondrial membrane potential^[1].

POLRMT-IN-2 (0-10 μM, 48 h) induces apoptosis and reduces the expression of both AKT and p-AKTSer473 in MOLM-13 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

MOLM 13 cells
Concentration:

5 μM
Incubation Time:

48 h
Result:

Increased the positive areas of tunel staining.

Western Blot Analysis^[1]

Cell Line:

MOLM 13 cells
Concentration:

0, 2.5, 5, 10 μM
Incubation Time:

48 h
Result:

Increased the expression of apoptosis marker Bax significantly.
Decreased the expression of Bcl-2 was significantly.

Chemical Information

분자량 576.64
화학식 C₃₄H₃₂N₄O₅
SMILES

CC1=CC=C(C(C)=C1)C2=CC(OC3=C2C=CC(O[C@@H](C(N4C5CN(C(NC6=CC=CC(C#N)=C6)=O)CC4CC5)=O)C)=C3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu T, Cheng X, Wang Y, Hao W, Wang H, Zhang K, Wang J. Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia. Chem Biol Drug Des. 2025 May;105(5):e70127. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유