Z-GGF-CMK
Based on 1 Customer Validation
Z-GGF-CMK is an Antibacterial agent, an inhibitor of the ClpP1P2 serine protease complex (with an IC50 of 50 μM against intracellular ClpP1P2 protease activity in Mycobacterium bovis BCG), and a selective inhibitor of the mycobacterial Proteasome (with an IC50 of 50 μM against the proteasome in M. bovis BCG). Z-GGF-CMK inhibits the growth of mycobacteria. Z-GGF-CMK exhibits cytotoxic activity against liver cancer cells. Z-GGF-CMK can be used in the research of tuberculosis.
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- Purity : 99.74%
- CAS No.: 35172-59-9
- 화학식: C22H24ClN3O5
- 분자량:445.90
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
ClpP1P2 50 μM (IC50) |
In Vitro
Z-GGF-CMK (24 h) inhibits intracellular ClpP1P2 protease activity in M. bovis BCG with an IC50 of 50 μM[1].
Z-GGF-CMK (2 h) inhibits proteasome activity in M. bovis BCG with an IC50 of 50 μM[1].
Z-GGF-CMK (2 h) is inactive against human proteasome activity in HepG2 cells at concentrations up to 500 μM[1].
Z-GGF-CMK (5 days) inhibits M. bovis BCG growth with an MIC50 of 30 μM[1].
Z-GGF-CMK (5 days) inhibits M. tuberculosis H37Rv growth with an MIC50 of 30 μM[1].
Z-GGF-CMK exhibits cytotoxicity against HepG2 cells with a CC50 of 125 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 35172-59-9
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Appearance Solid
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분자량 445.90
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화학식 C22H24ClN3O5
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Color White to off-white
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Sequence
{Cbz}-Gly-Gly-Phe-{CMK}
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Sequence Shortening
{Cbz}-GGF-{CMK}
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (224.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2427 mL | 11.2133 mL | 22.4266 mL | 56.0664 mL |
| 5 mM | 0.4485 mL | 2.2427 mL | 4.4853 mL | 11.2133 mL | |
| 10 mM | 0.2243 mL | 1.1213 mL | 2.2427 mL | 5.6066 mL | |
| 15 mM | 0.1495 mL | 0.7476 mL | 1.4951 mL | 3.7378 mL | |
| 20 mM | 0.1121 mL | 0.5607 mL | 1.1213 mL | 2.8033 mL | |
| 25 mM | 0.0897 mL | 0.4485 mL | 0.8971 mL | 2.2427 mL | |
| 30 mM | 0.0748 mL | 0.3738 mL | 0.7476 mL | 1.8689 mL | |
| 40 mM | 0.0561 mL | 0.2803 mL | 0.5607 mL | 1.4017 mL | |
| 50 mM | 0.0449 mL | 0.2243 mL | 0.4485 mL | 1.1213 mL | |
| 60 mM | 0.0374 mL | 0.1869 mL | 0.3738 mL | 0.9344 mL | |
| 80 mM | 0.0280 mL | 0.1402 mL | 0.2803 mL | 0.7008 mL | |
| 100 mM | 0.0224 mL | 0.1121 mL | 0.2243 mL | 0.5607 mL |
Z-GGF-CMK Related Classifications
HY-P4284 Related Classifications
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