Sphingoid Bases

MSDH is a key enzyme in the biosynthesis of Coenzyme Q10, a vital component in cellular energy production.

3-Keto sphinganine (d18:0) serves as the substrate for 3-keto-dihydrosphingosine reductase in the de novo sphingolipid synthesis pathway, and is a key intermediate in the de novo synthesis of sphingoid long-chain bases. 3-Keto sphinganine (d18:0) can be used in studies related to thrombocytopenia, anemia.

Sulfobacin B is a competitive von Willebrand factor receptor GPIb/IX inhibitor with an IC₅₀ of 2.2 μM. Sulfobacin B inhibits binding of von Willebrand factor to GPIb/IX in a competitive manner. Sulfobacin B can be used for the research of thrombosis.

1-desoxymethylsphinganine is a sphingoid base which is the 1-deoxymethyl derivative of sphinganine.

3-Ketosphingosine trifluoroacetate is a chemically modified sphingomyelin analog with specific enzymatic pathway research activity. It is mainly used to explore the functions of sphingomyelin kinases and lyases in sphingomyelin metabolism. 3-Ketosphingosine trifluoroacetate has important application value in the study of cell signal transduction and related diseases. The study of 3-Ketosphingosine trifluoroacetate helps to deepen the understanding of sphingomyelin-related biological processes.

D-Erythro-sphingosyl phosphoinositol is a lipid nanoparticle covalently linked to an antibody with potential activity in targeted compound delivery. D-Erythro-sphingosyl phosphoinositol can enhance the accumulation of compounds in specific cell types. D-Erythro-sphingosyl phosphoinositol may be used as a ligand to enhance the effect of antibodies in immunosuppression. D-Erythro-sphingosyl phosphoinositol can also be used to study the mechanisms related to cell signaling and lipid metabolism.

1-Deoxysphingosine is elevated in lymphoblasts of individuals with hereditary sensory neuropathy type 1 (HSAN1) disorder; it features a (4E) double bond in its structure and is produced through the catabolism of 1-deoxyceramide catalyzed by the ceramidase enzyme, classifying it as an unsaturated deoxy-sphingoid base.

Sphingosyl PE (d18:1) is a kind of biochemical reagent.

N-12:0-1-Deoxysphinganine is a kind of biochemical reagent.

Fumonisin B4 is a derivative of fumonisin. Fumonisin B4 has low albumin binding capacity.

W140 (TFA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor.

Paecilaminol (FKI-0550) is potent NADH-fumarate reductase inhibitor. Paecilaminol exhibits an IC₅₀ value of 5.1 μM against Ascaris suum NADH-fumarate reductase.

Lyso-sulfatide (bovine) is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions.

4E,8Z-Sphingadiene is a sphingosine.

C12 Sphingosyl PE (d17:1/12:0) is a phosphosphingolipid.

N-Glycine lactosylsphingosine (d18:1) is a glycinated lactosylsphingosine.

(2S)-3-Keto sphinganine (d6:0) ((2S)-3-Keto-C6-dihydrosphingosine) hydrochloride is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.

N-Glycine galactosylsphingosine (d18:1) (N-Glycine psychosine) is a glycinated form of galactosylsphingosine (HY-136490).

Lactosylceramide (LacCer) (porcine RBC) is an endogenous bioactive sphingolipid. Lactosylceramide (porcine RBC) plays a pivotal role in mediating innate immune functions.