2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from S. enterica serotype typhimurium

Lipopolysaccharides, from S. enterica serotype typhimurium  (Synonyms: LPS, from Salmonella enterica (Serotype typhimurium))

製品番号: HY-D1056C3
COA 取扱説明書 Technical Support

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium are lipopolysaccharide endotoxins and TLR4 activators derived from serotype typhimurium of Salmonella enterica, and are classified as S-type LPS. Lipopolysaccharides, from S. enterica exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype typhimurium can modulate the fate of bacteria in dendritic cells (DC), determining the uptake, degradation, and activation of immune functions by DC cells against the bacteria.
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Lipopolysaccharides, from S. enterica serotype typhimurium

Lipopolysaccharides, from S. enterica serotype typhimurium 構造式

容量 価格（税別） 在庫状況 数量
1 mg $80 在庫あり
5 mg $196 在庫あり
10 mg $315 在庫あり
25 mg $625 在庫あり
50 mg $1000 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Lipopolysaccharides, from S. enterica serotype typhimurium 関連抗体

Top Publications Citing Use of Products

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype typhimurium are lipopolysaccharide endotoxins and TLR4 activators derived from serotype typhimurium of Salmonella enterica, and are classified as S-type LPS. Lipopolysaccharides, from S. enterica exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype typhimurium can modulate the fate of bacteria in dendritic cells (DC), determining the uptake, degradation, and activation of immune functions by DC cells against the bacteria[1][2][3][4].
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

IC50 & Target

TLR-4[2]
体外実験

Note:
1. To maintain the integrity of LPS, it is recommended to store LPS solution in silanized containers. This is because LPS can adhere to plastics and certain types of glass, particularly at concentrations below 0.1 mg/mL. If concentration of LPS is higher than 1 mg/mL, this adsorption effect is relatively small, it is recommended to prepare ≥2 mg/mL stock solution, vortex thoroughly for more than 10 minutes, and use ultrasound to assist dissolution if necessary, and ensure sufficient mixing and dissolution. If using glass containers, ensure that the solution is thoroughly mixed for at least 30 minutes before use to redissolve any LPS that may have adsorbed to the tube walls.
2. LPS is a molecule capable of forming micelles of varying sizes in solution, and its molecular weight is not fixed. Both the stock solution and working solution can be prepared directly based on mass concentration (mg/mL, μg/mL, etc.).
3. Upon dissolution in water or PBS, LPS may form a uniformly turbid solution. For sterilization, DO NOT filter the stock solution directly. It is recommended to dilute the stock solution to the working concentration before sterilizing through a 0.22 μm filter membrane.

Lipopolysaccharides, from S. enterica serotype typhimurium are lipopolysaccharides distinct from those secreted by common Salmonella species. The LPS of common Salmonella species has only one wild-type core oligosaccharide structure (the Ra core in serotype Typhimurium), whereas Lipopolysaccharides, from S. enterica serotype typhimurium differ from the Ra core in a single terminal branch of the outer core, which may determine different immunogenicity[1]. S. enterica serotype typhimurium possesses two Wzz proteins: WzzST (which sets the modal range of O-antigen to 16–35 repeat units[RU]) and WzzfepE (which sets the modal value above 100 RU) (RU: sugar repeat units). The Wzz proteins regulate the length of the O-antigen in Lipopolysaccharides, and the number of RUs attached to lipid A is determined by the modal value set by the Wzz proteins. Mutations in the corresponding protein-coding genes lead to the formation of short-chain O-antigens and significantly reduce bacterial pathogenicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from S. enterica serotype typhimurium 関連抗体
Appearance

Solid

Color

White to off-white

SMILES

[Lipopolysaccharides, from S. enterica serotype typhimurium]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション

COA (240 KB)

取扱説明書 (2659 KB)
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Lipopolysaccharides, from S. enterica serotype typhimurium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from S. enterica serotype typhimuriumLPS, from Salmonella enterica (Serotype typhimurium)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Lipopolysaccharides, from S. enterica serotype typhimurium
製品番号:
HY-D1056C3
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.