Lopinavir Metabolite M-1

Name: Lopinavir Metabolite M-1
Brand: MedChemExpress
SKU: HY-136703
Rating: 4.5 (0 reviews)

Cat. No.: HY-136703: Ficha de datos Instrucciones de manejo
FAQs
Technical Support

Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a K_i of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro.

Para uso exclusivo en investigación. No vendemos a pacientes.

Lopinavir Metabolite M-1 Estructura química

No. CAS : 192725-39-6

Tamaño	Stock	Cantidad
1 mg	Obtener un presupuesto 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
5 mg	Obtener un presupuesto 4 - 5 weeks 5 - 6 weeks 6 - 7 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

Synthetic products have potential research and development risk.

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a K_i of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro^[1]^[2].

IC₅₀ & Target

IC50: 0.7 pM (HIV Protease)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	EC₅₀	0.14 μM Compound: 1j	Tested for cytopathic effect of HIVIIIB in MT-4 cells in presence of 50% human serum Tested for cytopathic effect of HIVIIIB in MT-4 cells in presence of 50% human serum	[PMID: 15109669]
MT4	EC₅₀	1.413 μM Compound: M-1	Antiviral activity against HIV in presence of 50% human serum in MT-4 cell was determined Antiviral activity against HIV in presence of 50% human serum in MT-4 cell was determined	[PMID: 11378352]

In Vitro

Lopinavir Metabolite M-1 has antiviral activities in MT-4 cells, with an EC₅₀ of 1.413 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

642.78

Fòrmula

C₃₇H₄₆N₄O₆

No. CAS

192725-39-6

SMILES

O=C(N[C@@H](CC1=CC=CC=C1)C[C@H](O)[C@@H](NC(COC2=C(C)C=CC=C2C)=O)CC3=CC=CC=C3)[C@H](C(C)C)N(C(N4)=O)CCC4=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3. [Content Brief]

[2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8. [Content Brief]