country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184917

Copy Link Print Information

MAO-B-IN-60

MAO-B-IN-60 is a selective MAO-B inhibitor with blood-brain barrier permeability, with an IC₅₀ of 0.07 nM. MAO-B-IN-60 exhibits region-specific MAO-B binding ability in rat brains. MAO-B-IN-60 can be used for the research of neurodegenerative diseases.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₁₈H₁₆F₃N₃O₂
Masse moléculaire:363.33

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MAO-B-IN-60 Chemical Structure

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

MAO-B

0.07 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Monoamine Oxidase :

MAO-A
MAO-B

In Vitro

MAO-B-IN-60 (Compound 32) potently inhibits recombinant human MAO-B, with over 10000-fold selectivity over MAO-A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[¹⁸F]MAO-B-IN-60 (7.90−14.39 MBq; intravenous injection; single administration) rapidly crosses the blood-brain barrier of normal SD rats, reaching a whole-brain uptake peak of 1.40 SUV within 1 minute post-injection^[1].
[¹⁸F]MAO-B-IN-60 (96.2−122.1 MBq; intravenous injection; single administration) exhibits brain region-specific accumulation matching the distribution of MAO-B in normal SD rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) rats (male, 5-11 weeks old, 152-372 g)^[1]
Dosage:

7.90-14.39 MBq (corresponding to 0.297-0.422 nM/kg)
Administration:

i.v.; single dose
Result:

Reached a peak whole-brain uptake of 1.40 SUV within 1 minute post-injection in baseline scans.
Decreased to 0.91 SUV at 25 minutes post-injection in baseline scans.

Animal Model:

Sprague-Dawley (SD) rats (male, 11 weeks old, 298-372 g)^[1]
Dosage:

96.2-122.1 MBq
Administration:

i.v.; single dose
Result:

Exhibited widespread distribution in the cortex and pronounced accumulation in MAO-B-rich regions including the cerebellum, cingulum, lacunosum-moleculare of the hippocampus, and ependymal cells of the lateral and fourth ventricles.

Chemical Information

Masse moléculaire 363.33
Formule C₁₈H₁₆F₃N₃O₂
SMILES

FC(C=C1NC(C2=CC=C3C(C=NN3CCOCCF)=C2)=O)=C(C=C1)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wu N, et al. Design, Synthesis, and Preliminary Evaluation of Fluorinated Indazole-5-carboxamide Derivatives for MAO-B PET Imaging. Journal of medicinal chemistry. 2026 Jul 09;69(13):15840-15857. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

MAO-B-IN-60

Voir tous les produits spécifiques à Isoform Monoamine Oxidase