MBC-11 trisodium
MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. MBC-11 trisodium has the potential for tumor-induced bone disease (TIBD) research.
For research use only. We do not sell to patients.
- CAS No.: 387877-45-4
- Formula: C11H17N3Na3O14P3
- Molecular Weight:577.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MBC-11 shows similar activity profiles and significantly inhibits growth of all three cell lines between 10-8 and 10-4 M. MBC-11 decreases KAS-6/1 cell growth from approximately 56% at 10-8 M to 6% at 10-5 M[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human multiple myeloma cell lines (KAS-6/1, DP-6, KP-6).
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Concentration:Between 10-8 and 10-4 M.
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Incubation Time:48 hours.
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Result:Significantly inhibited multiple myeloma cell proliferation of each cell line at the majority of the tested concentrations.
Weight gained in mice treated with up to 500 μg/day of MBC-11 is similar to the PBS treated group[1].
These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for tumor-induced bone disease (TIBD)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Approximately four-week old female Balb/c mice inoculated (s.c. injection into their mammary fatpads) with 500,000 4T1/luc cells at day 0 (breast tumor model)[1].
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Dosage:0.04, 0.4, or 4.0 μg/day.
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Administration:S.C. daily from day 7 to 21.
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Result:47% of 17 mice treated with MBC-11 had detectable bone metastases.
Chemical Information
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CAS No. 387877-45-4
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Appearance Solid
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Molecular Weight 577.15
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Formula C11H17N3Na3O14P3
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Color White to off-white
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SMILES
CC(P(O[Na])(O[Na])=O)(P(OP(O)(OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C=CC(N)=NC2=O)O1)=O)(O[Na])=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : 125 mg/mL (216.58 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (135 KB)
- English - EN (135 KB)
- Français - FR (135 KB)
- Deutsch - DE (135 KB)
- Norwegian - NO (135 KB)
- Español - ES (135 KB)
- Swedish - SV (135 KB)
- Italian - IT (135 KB)
- Korean - KR (135 KB)
- Portuguese - PT (135 KB)
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Handling Instructions (2659 KB)
References
[1]. Reinholz MM, et al. A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites. Bone. 2010 Jul;47(1):12-22. [Content Brief]
[2]. Zinnen SP, et al. First-in-Human Phase I Study of MBC-11, a Novel Bone-Targeted Cytarabine-Etidronate Conjugate in Patients with Cancer-Induced Bone Disease. Oncologist. 2019 Mar;24(3):303-e102. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7327 mL | 8.6633 mL | 17.3265 mL | 43.3163 mL |
| 5 mM | 0.3465 mL | 1.7327 mL | 3.4653 mL | 8.6633 mL | |
| 10 mM | 0.1733 mL | 0.8663 mL | 1.7327 mL | 4.3316 mL | |
| 15 mM | 0.1155 mL | 0.5776 mL | 1.1551 mL | 2.8878 mL | |
| 20 mM | 0.0866 mL | 0.4332 mL | 0.8663 mL | 2.1658 mL | |
| 25 mM | 0.0693 mL | 0.3465 mL | 0.6931 mL | 1.7327 mL | |
| 30 mM | 0.0578 mL | 0.2888 mL | 0.5776 mL | 1.4439 mL | |
| 40 mM | 0.0433 mL | 0.2166 mL | 0.4332 mL | 1.0829 mL | |
| 50 mM | 0.0347 mL | 0.1733 mL | 0.3465 mL | 0.8663 mL | |
| 60 mM | 0.0289 mL | 0.1444 mL | 0.2888 mL | 0.7219 mL | |
| 80 mM | 0.0217 mL | 0.1083 mL | 0.2166 mL | 0.5415 mL | |
| 100 mM | 0.0173 mL | 0.0866 mL | 0.1733 mL | 0.4332 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MBC-11 trisodium Related Classifications
HY-107093A Related Classifications
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