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MBC-11 trisodium salt 

Cat. No.: HY-107093A Purity: >98.0%
Handling Instructions

MBC-11 trisodium salt is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). Has potential to treat tumor-induced bone disease (TIBD).

For research use only. We do not sell to patients.

MBC-11 trisodium salt Chemical Structure

MBC-11 trisodium salt Chemical Structure

CAS No. : 387877-45-4

Size Price Stock Quantity
10 mM * 1 mL in Water USD 825 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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  • Biological Activity

  • Technical Information

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Description

MBC-11 trisodium salt is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). Has potential to treat tumor-induced bone disease (TIBD)[1].

In Vitro

MBC-11 shows similar activity profiles and significantly inhibits growth of all three cell lines between 10-8 and 10-4 M. MBC-11 decreases KAS-6/1 cell growth from approximately 56% at 10-8 M to 6% at 10-5 M[1]

Cell Proliferation Assay[1]

Cell Line: Human multiple myeloma cell lines (KAS-6/1, DP-6, KP-6).
Concentration: Between 10-8 and 10-4 M.
Incubation Time: 48 hours.
Result: Significantly inhibited multiple myeloma cell proliferation of each cell line at the majority of the tested concentrations.
In Vivo

MBC-11 (0.04 μg/day, s.c.) has a lower incidence of bone metastases of 40% compared to those treated with PBS (90%) or 0.04 μg/day zoledronate (100%). MBC-11 also significantly decreases bone tumor burden compared to PBS- or zoledronate-treated mice[1].
Weight gained in mice treated with up to 500 μg/day of MBC-11 is similar to the PBS treated group[1].
These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for tumor-induced bone disease (TIBD)[1].

Animal Model: Approximately four-week old female Balb/c mice inoculated (s.c. injection into their mammary fatpads) with 500,000 4T1/luc cells at day 0 (breast tumor model)[1].
Dosage: 0.04, 0.4, or 4.0 μg/day.
Administration: S.C. daily from day 7 to 21.
Result: 47% of 17 mice treated with MBC-11 had detectable bone metastases.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (216.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7327 mL 8.6633 mL 17.3265 mL
5 mM 0.3465 mL 1.7327 mL 3.4653 mL
10 mM 0.1733 mL 0.8663 mL 1.7327 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

577.15

Formula

C₁₁H₁₇N₃Na₃O₁₄P₃

CAS No.

387877-45-4

SMILES

CC(P(O[Na])(O[Na])=O)(P(OP(O)(OC[[email protected]@H]1[[email protected]@H](O)[[email protected]](O)[[email protected]](N2C=CC(N)=NC2=O)O1)=O)(O[Na])=O)O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
MBC-11 trisodium salt
Cat. No.:
HY-107093A
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MBC-11 trisodium salt

Cat. No.: HY-107093A