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Cat. No.: HY-185845

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MC-VC-PAB-PEG4-DBCO

MC-VC-PAB-PEG4-DBCO is a protease-cleavable ADC linker composed of Mc-VC-PAB and PEG4-DBCO moieties.

For research use only. We do not sell to patients.

Formula: C₅₈H₇₅N₉O₁₄
Molecular Weight:1122.27

Storage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

MC-VC-PAB-PEG4-DBCO Chemical Structure

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity

Description

MC-VC-PAB-PEG4-DBCO is a protease-cleavable ADC linker composed of Mc-VC-PAB and PEG4-DBCO moieties^[1].

All ADC Linkers Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 1122.27
Formula C₅₈H₇₅N₉O₁₄
Color White to off-white
SMILES

O=C(CCOCCOCCOCCOCCNC(OCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)NCCC(N3CC4=C(C#CC5=C3C=CC=C5)C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu SF, et al. A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Jul 15;21(14):3298-306. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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MC-VC-PAB-PEG4-DBCO

All ADC Linkers Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MC-VC-PAB-PEG4-DBCO Related Classifications

HY-185845 Related Classifications

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