mDPR-Val-Cit-PAB-MMAE TFA

製品番号: HY-19813A 純度: 98.36%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

mDPR-Val-Cit-PAB-MMAE TFA is a drug-linker conjugate for ADC (Drug-Linker Conjugates for ADC), consisting of a tubulin polymerization inhibitor MMAE (HY-15162) and an ADC linker (peptide Val-Cit- PAB) composition^{[1]^.}

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

mDPR-Val-Cit-PAB-MMAE TFA 構造式

CAS 番号 : 2185872-76-6

容量	価格（税別）	在庫状況	数量
1 mg	$420	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1050	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

分子量

1403.58

分子式

C₆₇H₁₀₁F₃N₁₂O₁₇

CAS 番号

2185872-76-6

Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](N4C(C=CC4=O)=O)CN)=O)=O)=O)C=C3)=O)C)=O)=O)C.O=C(O)C(F)(F)F

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (71.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7125 mL	3.5623 mL	7.1246 mL
5 mM	0.1425 mL	0.7125 mL	1.4249 mL
10 mM	0.0712 mL	0.3562 mL	0.7125 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.36%

Select Batch:

データシート (270 KB) SDS (252 KB)

COA (252 KB) HNMR (261 KB) LCMS (119 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Moquist, et al. Preparation of drug conjugates of IgG1 antibodies with self-stabilizing linkers having improved physiochemical properties for treating cancers and autoimmune diseases. World Intellectual Property Organization, WO2018031690 A1. 2018-02-15.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7125 mL	3.5623 mL	7.1246 mL	17.8116 mL
	5 mM	0.1425 mL	0.7125 mL	1.4249 mL	3.5623 mL
	10 mM	0.0712 mL	0.3562 mL	0.7125 mL	1.7812 mL
	15 mM	0.0475 mL	0.2375 mL	0.4750 mL	1.1874 mL
	20 mM	0.0356 mL	0.1781 mL	0.3562 mL	0.8906 mL
	25 mM	0.0285 mL	0.1425 mL	0.2850 mL	0.7125 mL
	30 mM	0.0237 mL	0.1187 mL	0.2375 mL	0.5937 mL
	40 mM	0.0178 mL	0.0891 mL	0.1781 mL	0.4453 mL
	50 mM	0.0142 mL	0.0712 mL	0.1425 mL	0.3562 mL
	60 mM	0.0119 mL	0.0594 mL	0.1187 mL	0.2969 mL