Methyltetrazine-PEG4-SS-NHS ester

Name: Methyltetrazine-PEG4-SS-NHS ester
Brand: MedChemExpress
SKU: HY-133466
Rating: 4.5 (0 reviews)

Cat. No.: HY-133466 Pureza: 95.0%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Para uso exclusivo en investigación. No vendemos a pacientes.

Methyltetrazine-PEG4-SS-NHS ester Estructura química

No. CAS : 2656478-52-1

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas ADC Linker:

Ver todas las isoformas

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

737.84

Fòrmula

C₃₁H₄₃N₇O₁₀S₂

No. CAS

2656478-52-1

Appearance

Oil

Color

Pink to red

SMILES

CC1=NN=C(C2=CC=C(CNC(CCOCCOCCOCCOCCNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)=O)C=C2)N=N1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 95.0%

Select Batch:

Ficha de datos (262 KB) SDS (393 KB)

COA (241 KB) HNMR (345 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]