MM-589 (racemic mixture ) TFA

Name: MM-589 (racemic mixture ) TFA
Brand: MedChemExpress
SKU: HY-100869B
Rating: 4.5 (0 reviews)

Cat. No.: HY-100869B Purity: 99.83%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MM-589 (racemic mixture) TFA, is a racemic mixture of MM-589 TFA (HY-100869A). MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC₅₀ of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC₅₀ of 12.7 nM.

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MM-589 (racemic mixture ) TFA 화학구조

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of MM-589 (racemic mixture ) TFA:

MM-589 TFA In-stock
MM-589 견적 받기

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

IC50: 12.7 nM (H3K4 methyltransferase), 0.90 nM (WDR5)^[1]

분자량

686.72

화학식

C₃₀H₄₅F₃N₈O₇

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2.O=C(NCC[C@](NC(C(C)C)=O)(C)C3=O)[C@@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N3)=O)CC)=O)C4=CC=CC=C4.OC(C(F)(F)F)=O.[(7:3)]

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 40 mg/mL (58.25 mM; ultrasonic and adjust pH to 2 with 1M HCl)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4562 mL	7.2810 mL	14.5620 mL
5 mM	0.2912 mL	1.4562 mL	2.9124 mL
10 mM	0.1456 mL	0.7281 mL	1.4562 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.83%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (254 KB) HNMR (395 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4562 mL	7.2810 mL	14.5620 mL	36.4049 mL
	5 mM	0.2912 mL	1.4562 mL	2.9124 mL	7.2810 mL
	10 mM	0.1456 mL	0.7281 mL	1.4562 mL	3.6405 mL
	15 mM	0.0971 mL	0.4854 mL	0.9708 mL	2.4270 mL
	20 mM	0.0728 mL	0.3640 mL	0.7281 mL	1.8202 mL
	25 mM	0.0582 mL	0.2912 mL	0.5825 mL	1.4562 mL
	30 mM	0.0485 mL	0.2427 mL	0.4854 mL	1.2135 mL
	40 mM	0.0364 mL	0.1820 mL	0.3640 mL	0.9101 mL
	50 mM	0.0291 mL	0.1456 mL	0.2912 mL	0.7281 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.