N,N-dimethyldithiocarbamate potassium
N,N-dimethyldithiocarbamate potassium is a ubiquitin-activating enzyme E1 inhibitor. N,N-dimethyldithiocarbamate potassium inhibits the activation of E1 and reduces the level of activated ubiquitinated E1 (ub-E1). N,N-dimethyldithiocarbamate potassium increases intracellular copper levels, enhances oxidative stress, elevates protein carbonyl levels, and upregulates the expression of HO-1. N,N-dimethyldithiocarbamate potassium is applicable to research related to Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 128-03-0
- Formula: C3H6KNS2
- Molecular Weight:159.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HO-1 |
In Vitro
N,N-dimethyldithiocarbamate (potassium) (20 μM; 6 h) inhibits ubiquitin-activating enzyme E1 activation in HEK293 cells, reducing the ub-E1/E1 ratio to 0.25 relative to control, with no detectable covalent E1 adducts[1].
N,N-dimethyldithiocarbamate (20 μM; 6 h) potassium significantly increases heme oxygenase-1 protein expression, a marker of oxidative stress, in HEK293 cells[1].
N,N-dimethyldithiocarbamate (20 μM; 6 h) potassium significantly elevates intracellular copper levels in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:20 μM
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Incubation Time:6 h
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Result:Significantly decreased the ub-E1/E1 ratio to 0.25 relative to control (p < 0.01, n = 5).
Detected no dithiocarbamate-derived E1 adducts (S-methylaminocarbonyl or glutathiotinylation) in E1-enriched cell extracts via LC/MS/MS. Significantly increased protein carbonyl levels relative to control (p < 0.05, n = 5). Significantly increased HO-1 protein expression relative to control (p < 0.01, n = 5).
Chemical Information
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CAS No. 128-03-0
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Molecular Weight 159.31
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Formula C3H6KNS2
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SMILES
S=C(N(C)C)S[K]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N,N-dimethyldithiocarbamate potassium Related Classifications
HY-W679138 Related Classifications
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