2. Membrane Transporter/Ion Channel
  3. Sodium Channel Sodium Phosphate Cotransporter
  4. NaPi2b-IN-1

NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia.

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NaPi2b-IN-1

NaPi2b-IN-1 Estructura química

No. CAS : 1453116-06-7

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NaPi2b-IN-1 Related Antibodies

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Descripciòn

NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia[1].

Parmacokinetics
Species Dose Route AUC0-∞ Bioavailability Cmax T1/2 AUC0-t MRT
Rat[1] 30 mg/kg p.o. 2.62 ng·h/mL 0.1 % 0.444 ng/mL 3.53 h 0.665 ng·h/mL 5.25 h
Rat[1] 0.5 mg/kg i.v. 2.62 ng·h/mL 0.1 % / / / /
Peso molecular

943.46

Fòrmula

C44H58ClF3N4O11S
No. CAS
SMILES

FC(F)(F)C(C=C1/C=N/NC(C2=C(NC(C3=CC(COCCOCCOCCOCCOCCOCCN(CC(O)=O)CCOC)=CC=C3)=O)SC4=C2CCC(C)(C)C4)=O)=C(C=C1)Cl
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Room temperature in continental US; may vary elsewhere.
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NaPi2b-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NaPi2b-IN-11453116-06-7Sodium ChannelSodium Phosphate CotransporterNa channelsNa+ channelssmall intestinelungtestehyperphosphatemiaInhibitorinhibitorinhibit

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Nombre del producto:
NaPi2b-IN-1
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HY-142957
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