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Cat. No.: HY-139611R

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Navlimetostat (Standard)

Name: Navlimetostat (Standard)
Brand: MedChemExpress
SKU: HY-139611R
Availability: PreOrder

(Synonyms: MRTX-1719 (Standard); BMS-986504 (Standard))

Navlimetostat (Standard) is the analytical standard of Navlimetostat (HY-139611). This product is intended for research and analytical applications. Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC₅₀ of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with K_d value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study.

For research use only. We do not sell to patients.

CAS No.: 2630904-45-7
Formula: C₂₃H₁₈ClFN₆O₂
Molecular Weight:464.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Navlimetostat (Standard) Chemical Structure

CAS No.: 2630904-45-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2630904-45-7
Molecular Weight 464.88
Formula C₂₃H₁₈ClFN₆O₂
SMILES

FC1=C(C=C(C(C#N)=[C@]1[C@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl
Synonyms

MRTX-1719 (Standard); BMS-986504 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lars D Engstrom, et al. MRTX1719 is an MTA-cooperative PRMT5 inhibitor that exhibits synthetic lethality in preclinical models and patients with MTAP deleted cancer. Cancer Discov. 2023 Aug 8;CD-23-0669. [Content Brief]

[2]. Christopher R Smith, et al. Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers. J Med Chem. 2022 Feb 10;65(3):1749-1766. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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