NGD 98-2

Cat. No.: HY-114070: Fiche technique Instruction de manipulation
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NGD 98-2 is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist

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NGD 98-2 Chemical Structure

CAS No. : 355836-54-3

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This product is a controlled substance and not for sale in your territory.

Other Forms of NGD 98-2:

NGD 98-2 hydrochloride Obtenir un devis

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform CRFR:

Voir toutes les isoformes

CRFR1 CRFR2

Activité biologique
Pureté et documentation
Références
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Description

NGD 98-2 is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist

Cellular Effect

Cell Line	Type	Value	Description	References
IMR-32	IC₅₀	93 nM Compound: 59, NGD 98-2	Inhibition of human CRF-1 receptor expressed in human IMR-32 cells assessed as effect on cAMP production by ELISA in presence of 3 nM CRF Inhibition of human CRF-1 receptor expressed in human IMR-32 cells assessed as effect on cAMP production by ELISA in presence of 3 nM CRF	[PMID: 21618986]

Masse moléculaire

399.41

Formule

C₁₉H₂₄F₃N₃O₃

CAS No.

355836-54-3

SMILES

CC1=C(C2=CC=C(OC(F)(F)F)C=C2OC)N=C(OC)C(NC(CC)CC)=N1

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem. 2011 Jun 23;54(12):4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. PMID: 21618986. [Content Brief]

[2]. Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One. 2013 Sep 6;8(9):e73749. doi: 10.1371/journal.pone.0073749. PMID: 24040053; PMCID: PMC3765344. [Content Brief]

NGD 98-2 Related Classifications

Neurological Disease

Calculateur de molarité
Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NGD 98-2355836-54-3CRFRCorticotropin-releasing Factor ReceptorCRHRInhibitorinhibitorinhibit

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