6PPD-Q
Based on 7 publication(s) in Google Scholar
6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 2754428-18-5
- Formula: C18H22N2O2
- Molecular Weight:298.38
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 6PPD-Q
More- J Adv Res. 2025 Mar 19:S2090-1232(25)00193-6. [Abstract]
- Environ Sci Technol. 2025 Jan 28;59(3):1542-1552. [Abstract]
- Sci Total Environ. 2025 Feb 10:964:178626. [Abstract]
- Environ Pollut. 2026 Apr 1:394:127701. [Abstract]
- Environ Pollut. 2025 Sep 23:385:127152. [Abstract]
- J Water Process Eng. 2025 Sep.
- Environ Sci Eur. 2026 Feb 21;38(1):71.
Customer Validation & Images
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
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WB
All α-synuclein Isoforms
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Biological Activity
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α-synuclein Aggregation |
6PPD-Q (10 nM, 100 nM, 7 days) increases α-syn aggregation in primary dopaminergic neurons, enhances α-syn PFF-induced p-α-synSer129 expression, and promotes its accumulation in mitochondria[2]. 6PPD-Q (10 nM, 100 nM, 7 days) reduces mitochondrial respiration in primary dopaminergic neurons, particularly under α-syn PFF (α-synuclein preformed fibrils) treatment conditions[2]. 6PPD-Q (10 nM, 100 nM, 7 days) decreases glycolysis metabolites and alters TCA cycle intermediates in primary dopaminergic neurons, leading to a reduction in glycolysis metabolites (e.g., fructose-6-phosphate, pyruvate) and TCA cycle intermediates (e.g., citrate, α-ketoglutarate)[2]. 6PPD-Q (10 nM, 100 nM, 48 hours) does not exhibit significant cytotoxicity in primary dopaminergic neurons[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary dopaminergic neurons
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Concentration:10 nM, 100 nM
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Incubation Time:48 hours
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Result:Did not exhibit apparent cytotoxicity.
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Cell Line:Primary dopaminergic neurons
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Concentration:10 nM, 100 nM
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Incubation Time:7 days
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Result:Significantly increased Triton X-100-insoluble α-synuclein (α-syn) protein levels.
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Cell Line:Primary dopaminergic neurons
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Concentration:10 nM, 100 nM
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Incubation Time:7 days
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Result:Enhanced α-syn PFF-induced p-α-synSer129 expression and co-localized primarily in mitochondria.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6PPD-Q-induced intestinal injury ICR mouse model[3]
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Dosage:0.1, 1, 10, 100 μg/kg
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Administration:Oral gavage (p.o.), once daily for 21 days
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Result:Dose-dependently disrupted intestinal barrier integrity, primarily affecting the jejunum and ileum, with no significant impact on the duodenum and colon. At exposure doses ≥10 μg/kg, TNF-α, IL-1, and IL-6 levels significantly increased, indicating intestinal inflammation.
Chemical Information
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CAS No. 2754428-18-5
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Appearance Solid
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Molecular Weight 298.38
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Formula C18H22N2O2
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Color Brown to red
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SMILES
O=C1C(NC(C)CC(C)C)=CC(C(NC2=CC=CC=C2)=C1)=O
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Synonyms
6PPD-Quinone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (7)
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Journal Impact Factor
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Most Recent
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J Adv Res
Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice. [Abstract]2025 Mar 19:S2090-1232(25)00193-6. PMID: 40118340 -
Environ Sci Technol
Long-Term Exposure to Tire-Derived 6-PPD Quinone Causes Neurotoxicity and Neuroinflammation via Inhibition of HTR2A in C57BL/6 Mice. [Abstract]2025 Jan 28;59(3):1542-1552. PMID: 39810414 -
Sci Total Environ
Exploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney disease. [Abstract]2025 Feb 10:964:178626. PMID: 39862509 -
Environ Pollut
TRPM2 mediates tire-derived pollutant 6PPD-Q-induced male reproductive impairment via autophagy in mice. [Abstract]2026 Apr 1:394:127701. PMID: 41554427
6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701. [Abstract]
6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) resulted in substantial damage to testicular tissue in 6-week-old male BALB/c mice.
6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701. [Abstract]
6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) exhibited a significant reduction in body weight. However, the testicular index remained unchanged in 6-week-old male BALB/c mice.
6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701. [Abstract]
6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) reduced sperm concentration in the tubules in 6-week-old male BALB/c mice.
6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701. [Abstract]
6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) reduced SOD activity and increased MDA levels in the testicular tissue of 6-week-old male BALB/c mice.
6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701. [Abstract]
6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) decreased levels of Bcl-2 (p < 0.01) alongside increased levels of Bax and cleaved caspase-3 (p < 0.01) in the 6PPD-Q group.
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Environ Pollut
Route-dependent toxicodynamics of 6PPD-quinone in mussels: Mechanical resilience trades off with subcellular injury and metabolic disruption. [Abstract]2025 Sep 23:385:127152. PMID: 40998148 -
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Solvent & Solubility
DMSO : 5 mg/mL (16.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 1.25 mg/mL (4.19 mM); Suspended solution; Need ultrasonic
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[2]. Fang J, et al. 6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding. J Hazard Mater. 2024 Mar 5;465:133312. [Content Brief]
[3]. Yang Y, et al. Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation[J]. Science of The Total Environment, 2024, 918: 170679. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3514 mL | 16.7572 mL | 33.5143 mL | 83.7858 mL |
| 5 mM | 0.6703 mL | 3.3514 mL | 6.7029 mL | 16.7572 mL | |
| 10 mM | 0.3351 mL | 1.6757 mL | 3.3514 mL | 8.3786 mL | |
| 15 mM | 0.2234 mL | 1.1171 mL | 2.2343 mL | 5.5857 mL |
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