NR2F2-IN-1 free base

Cat. No.: HY-156190A Purity: 99.31%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

NR2F2-IN-1 free base 화학구조

CAS No. : 452087-38-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of NR2F2-IN-1 free base:

NR2F2-IN-1 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

분자량

329.42

화학식

C₁₇H₁₉N₃O₂S

CAS No.

452087-38-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (379.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0356 mL	15.1782 mL	30.3564 mL
5 mM	0.6071 mL	3.0356 mL	6.0713 mL
10 mM	0.3036 mL	1.5178 mL	3.0356 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.31%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) HNMR (256 KB) RP-HPLC (249 KB) MS (229 KB)

Handling Instructions (2659 KB)

References

[1]. Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6(18):eaaz8031. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0356 mL	15.1782 mL	30.3564 mL	75.8910 mL
	5 mM	0.6071 mL	3.0356 mL	6.0713 mL	15.1782 mL
	10 mM	0.3036 mL	1.5178 mL	3.0356 mL	7.5891 mL
	15 mM	0.2024 mL	1.0119 mL	2.0238 mL	5.0594 mL
	20 mM	0.1518 mL	0.7589 mL	1.5178 mL	3.7945 mL
	25 mM	0.1214 mL	0.6071 mL	1.2143 mL	3.0356 mL
	30 mM	0.1012 mL	0.5059 mL	1.0119 mL	2.5297 mL
	40 mM	0.0759 mL	0.3795 mL	0.7589 mL	1.8973 mL
	50 mM	0.0607 mL	0.3036 mL	0.6071 mL	1.5178 mL
	60 mM	0.0506 mL	0.2530 mL	0.5059 mL	1.2648 mL
	80 mM	0.0379 mL	0.1897 mL	0.3795 mL	0.9486 mL
	100 mM	0.0304 mL	0.1518 mL	0.3036 mL	0.7589 mL