2. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. Akt Ser/Thr Protease
  4. NSC45586

NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons.

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NSC45586

NSC45586 화학구조

CAS No. : 739301-85-0

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NSC45586 Related Antibodies

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Akt Akt1 Akt2 Akt3

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제품 설명

NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons[1].

IC50 & Target

PHLPP1/2, Akt[1]
Cellular Effect
Cell Line Type Value Description References
COS-7 IC50
70 μM
Compound: 13, NSC-45586
Inhibition of PHLPP expressed in 24 hrs serum starved Cos7 cells assessed as increase of Akt phosphorylation after 30 mins by immunoblotting
Inhibition of PHLPP expressed in 24 hrs serum starved Cos7 cells assessed as increase of Akt phosphorylation after 30 mins by immunoblotting
[PMID: 20836557]
분자량

390.40

화학식

C20H18N6O3
CAS No.
SMILES

O=C(O)C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
용액&용해도
In Vitro: 

DMSO : 20.83 mg/mL (53.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5615 mL 12.8074 mL 25.6148 mL
5 mM 0.5123 mL 2.5615 mL 5.1230 mL
View the Complete Stock Solution Preparation Table

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순도&문서
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5615 mL 12.8074 mL 25.6148 mL 64.0369 mL
5 mM 0.5123 mL 2.5615 mL 5.1230 mL 12.8074 mL
10 mM 0.2561 mL 1.2807 mL 2.5615 mL 6.4037 mL
15 mM 0.1708 mL 0.8538 mL 1.7077 mL 4.2691 mL
20 mM 0.1281 mL 0.6404 mL 1.2807 mL 3.2018 mL
25 mM 0.1025 mL 0.5123 mL 1.0246 mL 2.5615 mL
30 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1346 mL
40 mM 0.0640 mL 0.3202 mL 0.6404 mL 1.6009 mL
50 mM 0.0512 mL 0.2561 mL 0.5123 mL 1.2807 mL
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NSC45586 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC45586739301-85-0NSC 45586NSC-45586AktSer/Thr ProteasePKBProtein kinase BSerine proteasesSerine endopeptidasesThreonine proteasespleckstrin homology domain and leucine-rich repeat protein phosphatasePHLPPPP2CPHLPP1PHLPP2AKTInhibitorinhibitorinhibit

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상품명:
NSC45586
Cat. No.:
HY-19820
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