Lipid Amine

DSPE-PEG-Amine (DSPE-PEG-NH2), MW 3400 ammonium is an amino-functionalized PEGylated phospholipid. It serves not only as a key component for preparing σ receptor-targeted liposomes (such as anisamide-modified lipids) but also as a starting material for synthesizing click chemistry- and tumor-targeted lipids including DSPE-PEG-DBCO (HY-155788) and DSPE-PEG2000-TCO (HY-170704). DSPE-PEG-Amine, MW 3400 ammonium effectively modulates the ζ potential of nanoparticles, enables complexation with nucleic acids or proteins to protect DNA from nuclease degradation, and supports ligand conjugation on the nanoparticle surface. It is used in studies related to DU-145 tumors, breast cancer, and other relevant research.

16:0 Caproylamine PE is an amide-functionalized lipid with a phosphoethanolamine linked to two palmitic acid tails.

18:1 Caproylamine PE is a amine-functionalized lipid with a phosphoethanolamine linked to two oleic acid tails.

DSPE-PEG3400-Amine is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. DSPE-PEG3400-Amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.

DSPE-PEG46-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

DSPE-PEG20000-Amine ammonium is an amine derivative of phospholipid-polyethylene glycol, which is used to synthesize solid lipid and thermosensitive liposome nanoparticles for the delivery of anticancer agents. DSPE-PEG20000-Amine ammonium is applicable for cancer research.

Oleoyl-Gly-Lys-(m-PEG11)-NH2 is a PEG-lipid molecule featuring an oleoyl amide linked to a Gly-Lys dipeptide and a methoxy PEG11 chain on the C-terminus of the lysine. The lysine primary amine may be used in a wide variety of reactions with carboxylic acids, NHS esters, and carbonyl groups. The PEG linker provides aqueous solubility.

NH2-GG-DSPE is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.