2. Epigenetics
  3. Protein Arginine Deiminase
  4. PAD4-IN-3

PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment.

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PAD4-IN-3

PAD4-IN-3 화학구조

CAS No. : 2642327-44-2

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PAD4-IN-3 Related Antibodies

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제품 설명

PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].

IC50 & Target

PAD4[1]
Cellular Effect
Cell Line Type Value Description References
4T1 IC50
> 100 μM
Compound: 5a
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 37421890]
분자량

444.72

화학식

C21H26BClN4O4
CAS No.
SMILES

O=C(NCC1=CC=CC=C1)[C@H](CCCNC(CCl)=N)NC(C2=CC(B(O)O)=CC=C2)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PAD4-IN-3 Related Classifications

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Keywords:

PAD4-IN-32642327-44-2Protein Arginine DeiminasePeptidylarginine DeiminaseOxidative stress responsive nanodrugsPeptidyl arginine deiminase 4 (PAD4) inhibitorsPhenylboronic acid estersRGD sequence peptidesTumor immune microenvironmentInhibitorinhibitorinhibit

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PAD4-IN-3
Cat. No.:
HY-157157
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