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Cat. No.: HY-184914

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Phenyl-glutarimide 4'-oxyacetic acid-PEG3

Phenyl-glutarimide 4'-oxyacetic acid-PEG3 is a PROTAC E3 ligase ligand-linker conjugate that can be used in PROTAC synthesis-related research, such as as the E3+ linker structure of JHK-02-102-1 (HY-184913).

For research use only. We do not sell to patients.

Formula: C₁₉H₂₆N₂O₇
Molecular Weight:394.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Phenyl-glutarimide 4'-oxyacetic acid-PEG3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 394.42
Formula C₁₉H₂₆N₂O₇
SMILES

O=C1C(CCC(N1)=O)C(C=C2)=CC=C2OCC(NCCOCCOCCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim JH, et al. A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition. J Am Chem Soc. 2026 Jul 8;148(26):27951-27964. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Phenyl-glutarimide 4'-oxyacetic acid-PEG3

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Biological Activity
- Description
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Chemical Information
Purity & Documentation
References

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Phenyl-glutarimide 4'-oxyacetic acid-PEG3

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Phenyl-glutarimide 4'-oxyacetic acid-PEG3 Related Classifications

HY-184914 Related Classifications

Bioz