Cat. No.: HY-N0952

(+)-Lyoniresinol 3α-O-β-D-glucopyranoside

Name: (+)-Lyoniresinol 3α-O-β-D-glucopyranoside
Brand: MedChemExpress
SKU: HY-N0952
Price: 100.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: (+)-Lyoniresinol 9'-O-glucoside)

Customer Review

Based on 1 Customer Validation

(+)-Lyoniresinol 3α-O-β-D-glucopyranoside (Compound 1) is a natural product that can be isolated from the bark of Aegle marmelos CORREA.

For research use only. We do not sell to patients.

Purity : 99.37%
CAS No.: 87585-32-8
Formula: C₂₈H₃₈O₁₃
Molecular Weight:582.59

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

(+)-Lyoniresinol 3α-O-β-D-glucopyranoside Chemical Structure

CAS No.: 87585-32-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(+)-Lyoniresinol 3α-O-β-D-glucopyranoside (Compound 1) is a natural product that can be isolated from the bark of Aegle marmelos CORREA^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>10 μg/mL Compound: page 1629, R25C1	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 17125236]
A549	IC₅₀	>10 μg/mL Compound: page 1629, R25C1	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 17125236]
A549	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 25894905]
Bel-7402	IC₅₀	>10 μg/mL Compound: page 1629, R25C1	Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay	[PMID: 17125236]
BGC-823	IC₅₀	>10 μg/mL Compound: page 1629, R25C1	Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay	[PMID: 17125236]
BMDC	IC₅₀	>50 μM Compound: 16	Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA	[PMID: 23484668]
BMDC	IC₅₀	>50 μM Compound: 16	Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA	[PMID: 23484668]
BMDC	IC₅₀	>50 μM Compound: 16	Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA	[PMID: 23484668]
BV-2	IC₅₀	37.7 μM Compound: 9	Antiinflammatory activity against LPS-stimulated mouse BV2 cells assessed as inhibition of nitric oxide production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay Antiinflammatory activity against LPS-stimulated mouse BV2 cells assessed as inhibition of nitric oxide production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay	[PMID: 25894905]
HCT-15	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human HCT15 cells by SRB assay Cytotoxicity against human HCT15 cells by SRB assay	[PMID: 25894905]
HCT-8	IC₅₀	>10 μg/mL Compound: page 1629, R25C1	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 17125236]
SK-MEL-2	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human SK-MEL-2 cells by SRB assay Cytotoxicity against human SK-MEL-2 cells by SRB assay	[PMID: 25894905]
SK-OV-3	IC₅₀	>10 μM Compound: 9	Cytotoxicity against human SKOV3 cells by SRB assay Cytotoxicity against human SKOV3 cells by SRB assay	[PMID: 25894905]

Chemical Information

CAS No. 87585-32-8
Appearance Solid
Molecular Weight 582.59
Formula C₂₈H₃₈O₁₃
Color White to off-white
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC[C@@H]2[C@@H](C3=CC(OC)=C(O)C(OC)=C3)C4=C(C=C(OC)C(O)=C4OC)C[C@H]2CO
Synonyms

(+)-Lyoniresinol 9'-O-glucoside
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (171.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7165 mL

8.5824 mL

17.1647 mL

5 mM

0.3433 mL

1.7165 mL

3.4329 mL

10 mM

0.1716 mL

0.8582 mL

1.7165 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ohashi K, et al. Indonesian medicinal plants. X. Chemical structures of four new triterpene-glycosides, gongganosides D, E, F, and G, and two secoiridoid-glucosides from the bark of Bhesa paniculata (Celastraceae). Chem Pharm Bull (Tokyo). 1994 Sep;42(9):1791-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7165 mL	8.5824 mL	17.1647 mL	42.9118 mL
	5 mM	0.3433 mL	1.7165 mL	3.4329 mL	8.5824 mL
	10 mM	0.1716 mL	0.8582 mL	1.7165 mL	4.2912 mL
	15 mM	0.1144 mL	0.5722 mL	1.1443 mL	2.8608 mL
	20 mM	0.0858 mL	0.4291 mL	0.8582 mL	2.1456 mL
	25 mM	0.0687 mL	0.3433 mL	0.6866 mL	1.7165 mL
	30 mM	0.0572 mL	0.2861 mL	0.5722 mL	1.4304 mL
	40 mM	0.0429 mL	0.2146 mL	0.4291 mL	1.0728 mL
	50 mM	0.0343 mL	0.1716 mL	0.3433 mL	0.8582 mL
	60 mM	0.0286 mL	0.1430 mL	0.2861 mL	0.7152 mL
	80 mM	0.0215 mL	0.1073 mL	0.2146 mL	0.5364 mL
	100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.4291 mL

Bioz

Keywords

(+)-Lyoniresinol 3α-O-β-D-glucopyranoside

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(+)-Lyoniresinol 3α-O-β-D-glucopyranoside

Biological Activity

Description

Cellular Effect

Chemical Information

Solvent & Solubility

In Vitro:

In Vivo:

In Vivo Dissolution Calculator

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(+)-Lyoniresinol 3α-O-β-D-glucopyranoside Related Classifications

HY-N0952 Related Classifications

Bioz

Keywords

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