Poly(ethylene glycol) diglycidyl ether (MW 500)
Based on 1 Customer Validation
Poly (ethylene glycol) diglycidyl ether (MW 500) is a crosslinker with epoxy functional groups at both ends. Poly (ethylene glycol) diglycidyl ether (MW 500) undergoes epoxy ring-opening reactions with the amino groups of ε-polylysine and the hydroxyl groups of hyaluronic acid to form a crosslinked network. Poly (ethylene glycol) diglycidyl ether (MW 500) helps endow materials with procoagulant, antibacterial and wound-healing properties.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 26403-72-5
- Molecular Weight:500 (Average)
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Poly (ethylene glycol) diglycidyl ether (MW 500)-crosslinked ε-polylysine hydrogels can promote blood coagulation. Among them, EPPE1 shows the shortest coagulation time (563 s), the lowest blood clotting index (35.89%), and the highest adhesion/activation levels of red blood cells and platelets, indicating its excellent in vitro hemostatic performance[1].
The hyaluronic acid gel prepared by cross-linking with Poly (ethylene glycol) diglycidyl ether (MW 658.38) (1.1 v/v%; 24 h) has a residual epoxy group content of less than 1 ppm, which meets the safety requirements for injectable soft tissue fillers[2].
Poly (ethylene glycol) diglycidyl ether (MW 500)-crosslinked ε-polylysine hydrogels exhibit excellent intrinsic antibacterial activity, among which EPPE1 and EPPE2 achieve a killing rate of approximately 99% against *Escherichia coli*, *Staphylococcus aureus* and multidrug-resistant *Staphylococcus aureus* by disrupting bacterial cell membranes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 26403-72-5
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Appearance Liquid (Density: 1.14 g/cm3)
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Molecular Weight 500 (Average)
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Color Colorless to light yellow
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SMILES
C1(CO1)COCCOCC2CO2.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yang X, et al. Inherent Antibacterial and Instant Swelling ε-Poly-Lysine/ Poly(ethylene glycol) Diglycidyl Ether Superabsorbent for Rapid Hemostasis and Bacterially Infected Wound Healing. ACS applied materials & interfaces. 2021 Aug 11;13(31):36709-36721. [Content Brief]
[2]. Peng F, et al. evaluation of hyaluronic acid gels crosslinked with 1,4-butanediol diglycidyl ether and poly(ethylene glycol) diglycidyl ether for soft-tissue augmentation. RSC advances. 2026 Jul 06. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly(ethylene glycol) diglycidyl ether (MW 500) Related Classifications
HY-W763546A Related Classifications
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