PPARα/δ agonist 1
Based on 1 Customer Validation
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist (PPARα EC50=7.0 nM; PPARδ EC50=8.4 nM). PPARα/δ agonist 1 is a high selectivity over PPARγ (PPARγ EC50=1316.1 nM). PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 2760128-48-9
- Formula: C22H22F3N3O5
- Molecular Weight:465.42
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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PPARα 7 nM (EC50) |
PPARδ 8.4 nM (EC50) |
PPARγ 1316.1 nM (EC50) |
Chemical Information
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CAS No. 2760128-48-9
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Appearance Solid
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Molecular Weight 465.42
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Formula C22H22F3N3O5
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Color White to off-white
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SMILES
O=C1N(N=CN1C2=CC=C(C=C2)OC(F)(F)F)CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (214.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1486 mL | 10.7430 mL | 21.4860 mL | 53.7149 mL |
| 5 mM | 0.4297 mL | 2.1486 mL | 4.2972 mL | 10.7430 mL | |
| 10 mM | 0.2149 mL | 1.0743 mL | 2.1486 mL | 5.3715 mL | |
| 15 mM | 0.1432 mL | 0.7162 mL | 1.4324 mL | 3.5810 mL | |
| 20 mM | 0.1074 mL | 0.5371 mL | 1.0743 mL | 2.6857 mL | |
| 25 mM | 0.0859 mL | 0.4297 mL | 0.8594 mL | 2.1486 mL | |
| 30 mM | 0.0716 mL | 0.3581 mL | 0.7162 mL | 1.7905 mL | |
| 40 mM | 0.0537 mL | 0.2686 mL | 0.5371 mL | 1.3429 mL | |
| 50 mM | 0.0430 mL | 0.2149 mL | 0.4297 mL | 1.0743 mL | |
| 60 mM | 0.0358 mL | 0.1790 mL | 0.3581 mL | 0.8952 mL | |
| 80 mM | 0.0269 mL | 0.1343 mL | 0.2686 mL | 0.6714 mL | |
| 100 mM | 0.0215 mL | 0.1074 mL | 0.2149 mL | 0.5371 mL |
PPARα/δ agonist 1 Related Classifications
HY-144111 Related Classifications
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