T Cell CD Proteins
The cluster of differentiation (CD) antigens a protocol used for the identification and investigation of cell surface molecules present on leukocytes. Some CD proteins often act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ion pores, or nutrient transporters. CD proteins play a variety of roles in immune system function. The lineage-specific marker for T cells is cytoplasmic CD3, which appears in the earliest T cells as precursors in the thymus. Early T-cell precursors also express CD2 and CD7. During thymic maturation, the T-cell precursor undergoes rearrangements of the T-cell receptor. This process is accompanied by the appearance of other T-cell lineage-associated markers (CD5, CD4, CD8). The majority of the mature T cells are either CD4+ or CD8+. Thymocytes, however, and aberrant neoplastic T cells may coexpress CD4 and CD8 as well as immature T-cell markers TdT and CD1a.
- PD-1 (36)
- 4-1BB (27)
- CD40 Ligand/CD154 (26)
- CTLA-4 (25)
- CD3D-CD3E Heterodimer Proteins (23)
- OX40 Ligand (18)
- CD3e (18)
- CD40 (18)
- CD314/NKG2D (17)
- RANKL/CD254 (17)
- CD28 (17)
- CD4 (16)
- CD38 (16)
- B7-1/CD80 (16)
- CD5 (15)
- CD8a (15)
- FcγRIIIA/CD16a (15)
- OX40/CD134 (14)
- IL-2R alpha/CD25 (14)
- IL-6RA/CD126 (14)
- CD218a/IL-18R alpha (14)
- CD27 (14)
- ICOS/CD278 (13)
- B7-2/CD86 (12)
- B7-H2/CD275 (11)
- CD30 (11)
- Fas/CD95 (10)
- CD73 (10)
- CD30L/CD153 (9)
- CD3E-CD3G Heterodimer Proteins (9)
- DPP IV/CD26 (9)
- CD39 (9)
- FasL/CD178 (8)
- CD83 (8)
- CD45 (7)
- L-Selectin/CD62L (6)
- CD3d (6)
- CD1d (5)
- CD8b (5)
- FcγRIIIB/CD16b (5)
- CD150 (5)
- Tetraspanin 7/CD231 (5)
- TLR3/CD283 (4)
- CD161/KLRB1 (4)
- TLR2/CD282 (3)
- CCR2/CD192 (3)
- TLR4/CD284 (2)
- CD1b (2)
- CD1a (2)
- CD3g (2)
- CD3ζ (1)
- CD1e (1)
- CD1c (1)