1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. PSEM 89S TFA

PSEM 89S TFA 

Cat. No.: HY-112217A
Handling Instructions

PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.

For research use only. We do not sell to patients.

PSEM 89S TFA Chemical Structure

PSEM 89S TFA Chemical Structure

CAS No. : 1336913-03-1

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Description

PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1].

In Vitro

PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC)[1].
PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance[1].

In Vivo

PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg)[1].
PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration[1].

Animal Model: Male Agrp-cre mice (3-6 weeks)[1]
Dosage: 30 mg/kg
Administration: I.p. administration
Result: Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons.
Animal Model: C57BL/6 mice[1]
Dosage: 30 mg/kg (Pharmacokinetic Analysis)
Administration: I.p. administration
Result: Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h.
Molecular Weight

404.38

Formula

C₁₈H₂₃F₃N₂O₅

CAS No.

1336913-03-1

SMILES

O=C(N[[email protected]@H]1CN2CCC1CC2)C3=CC(OC)=CC=C3OC.O=C(O)C(F)(F)F

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PSEM 89SnAChRNicotinic acetylcholine receptorsIonchannelsQ79GL141FGlyRPSAMInhibitorinhibitorinhibit

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PSEM 89S TFA
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HY-112217A
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