1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. PSEM 89S TFA

PSEM 89S TFA 

Cat. No.: HY-112217A
Handling Instructions

PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.

For research use only. We do not sell to patients.

PSEM 89S TFA Chemical Structure

PSEM 89S TFA Chemical Structure

CAS No. : 1336913-03-1

Size Price Stock Quantity
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1].

In Vitro

PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC)[1].
PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg)[1].
PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Agrp-cre mice (3-6 weeks)[1]
Dosage: 30 mg/kg
Administration: I.p. administration
Result: Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons.
Animal Model: C57BL/6 mice[1]
Dosage: 30 mg/kg (Pharmacokinetic Analysis)
Administration: I.p. administration
Result: Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h.
Molecular Weight

404.38

Formula

C₁₈H₂₃F₃N₂O₅

CAS No.

1336913-03-1

SMILES

O=C(N[[email protected]@H]1CN2CCC1CC2)C3=CC(OC)=CC=C3OC.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4729 mL 12.3646 mL 24.7292 mL
5 mM 0.4946 mL 2.4729 mL 4.9458 mL
10 mM 0.2473 mL 1.2365 mL 2.4729 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PSEM 89SnAChRNicotinic acetylcholine receptorsIonchannelsQ79GL141FGlyRPSAMInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PSEM 89S TFA
Cat. No.:
HY-112217A
Quantity:
MCE Japan Authorized Agent: