2. Membrane Transporter/Ion Channel
    Neuronal Signaling
  3. nAChR
  4. PSEM 89S TFA

PSEM 89S TFA 

Cat. No.: HY-112217A Purity: 99.81%
COA Handling Instructions

PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively.

For research use only. We do not sell to patients.

PSEM 89S TFA Chemical Structure

PSEM 89S TFA Chemical Structure

CAS No. : 1336913-03-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 165 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 480 In-stock
50 mg USD 750 In-stock
100 mg USD 1150 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1].

In Vitro

PSEM 89S (10 or 30μM) activates layer 2/3 cortical neurons expressing (Pharmacologically Selective Actuator Module) PSAML141F,Y115F-5HT3 high conductance (HC)[1].
PSEM 89S (10 μM) reversibly silenced transfected neurons by reducing cellular input resistance[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg)[1].
PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Agrp-cre mice (3-6 weeks)[1]
Dosage: 30 mg/kg
Administration: I.p. administration
Result: Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons.
Animal Model: C57BL/6 mice[1]
Dosage: 30 mg/kg (Pharmacokinetic Analysis)
Administration: I.p. administration
Result: Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h.
Molecular Weight

404.38

Appearance

Solid

Formula

C18H23F3N2O5
CAS No.
SMILES

O=C(N[[email protected]@H]1CN2CCC1CC2)C3=CC(OC)=CC=C3OC.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (247.29 mM)

DMSO : 100 mg/mL (247.29 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4729 mL 12.3646 mL 24.7292 mL
5 mM 0.4946 mL 2.4729 mL 4.9458 mL
10 mM 0.2473 mL 1.2365 mL 2.4729 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

PSEM 89S1336913-03-1nAChRNicotinic acetylcholine receptorsIonchannelsQ79GL141FGlyRPSAMInhibitorinhibitorinhibit

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