PSMA-azide
Based on 1 Customer Validation
PSMA-azide is a prostate-specific membrane antigen (PSMA) ligand. PSMA-azide inhibits PSMA-dependent NAAG (N-acetylaspartylglutamic acid) hydrolysis, with an IC50 of 9 nM and a Ki of 1 nM. PSMA-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups.
For research use only. We do not sell to patients.
- Purity: 98.06%
- CAS No.: 2374814-84-1
- Formula: C50H65ClN10O13
- Molecular Weight:1049.56
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 70
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Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 33822606] |
| HEK-293T | CC50 |
>100 μM
Compound: 70
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Cytotoxicity against HEK293T cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Cytotoxicity against HEK293T cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 33822606] |
| LNCaP | CC50 |
>100 μM
Compound: 70
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Cytotoxicity against human LNCaP cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human LNCaP cells assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 33822606] |
| MCF7 | CC50 |
>100 μM
Compound: 70
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 33822606] |
| PC-3 | CC50 |
>100 μM
Compound: 70
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 33822606] |
| WI-38 VA13 | CC50 |
>100 μM
Compound: 70
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Cytotoxicity against human WI-38 VA13 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Cytotoxicity against human WI-38 VA13 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 33822606] |
PSMA-azide (compound 70) is not cytotoxic up to 50-100 μM on the Hek293T, VA-13, MCF-7, A549, LNCaP and PC-3 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2374814-84-1
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Appearance Solid
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Molecular Weight 1049.56
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Formula C50H65ClN10O13
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Color White to off-white
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SMILES
O=C(N[C@H](C(NCCCN=[N+]=[N-])=O)CC(C=C1)=CC=C1O)[C@@H](NC(CCC(NCCCCCC(N(CCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)CC2=CC(Cl)=CC=C2)=O)=O)=O)CC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (190.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9528 mL | 4.7639 mL | 9.5278 mL | 23.8195 mL |
| 5 mM | 0.1906 mL | 0.9528 mL | 1.9056 mL | 4.7639 mL | |
| 10 mM | 0.0953 mL | 0.4764 mL | 0.9528 mL | 2.3820 mL | |
| 15 mM | 0.0635 mL | 0.3176 mL | 0.6352 mL | 1.5880 mL | |
| 20 mM | 0.0476 mL | 0.2382 mL | 0.4764 mL | 1.1910 mL | |
| 25 mM | 0.0381 mL | 0.1906 mL | 0.3811 mL | 0.9528 mL | |
| 30 mM | 0.0318 mL | 0.1588 mL | 0.3176 mL | 0.7940 mL | |
| 40 mM | 0.0238 mL | 0.1191 mL | 0.2382 mL | 0.5955 mL | |
| 50 mM | 0.0191 mL | 0.0953 mL | 0.1906 mL | 0.4764 mL | |
| 60 mM | 0.0159 mL | 0.0794 mL | 0.1588 mL | 0.3970 mL | |
| 80 mM | 0.0119 mL | 0.0595 mL | 0.1191 mL | 0.2977 mL | |
| 100 mM | 0.0095 mL | 0.0476 mL | 0.0953 mL | 0.2382 mL |
PSMA-azide Related Classifications
HY-160893 Related Classifications
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